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Inhibitory effects and mechanisms of cryptotanshinone on the growth of tamoxifen resistant breast cancer cells
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Hang LIU1, Li-jie XIA1, Jin-yao LI1, *, Ying ZHANG2, *
Acta Pharmaceutica Sinica | 2022, 57(9) : 2751 - 2758
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Acta Pharmaceutica Sinica | 2022, 57(9): 2751-2758
• Original Articles •
Inhibitory effects and mechanisms of cryptotanshinone on the growth of tamoxifen resistant breast cancer cells
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Hang LIU1, Li-jie XIA1, Jin-yao LI1, *, Ying ZHANG2, *
Affiliations
  • 1. Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China
  • 2. Guang'anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing 100053, China
Published: 2022-09-12 doi: 10.16438/j.0513-4870.2022-0348
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This study investigated the inhibitory effect and mechanisms of cryptotanshinone (CPT) on tamoxifen resistant cell MCF7-TAMR. The inhibitory effect of CPT on the viability of MCF7-TAMR cells was evaluated using the MTT assay. We found that CPT significantly inhibited the growth of MCF7-TAMR cells in a dose- and time-dependent manner. The half inhibitory concentration (IC50) is 15.14 ± 2.82 μmol·L-1 at 24 h. CPT induced cell cycle arrest of MCF7-TAMR cells at G0/G1 phase, and promoted apoptosis of MCF7-TAMR cells by upregulating intracellular levels of reactive oxygen species (ROS). Transwell results showed that CPT significantly inhibited the migration of MCF7-TAMR cells. Furthermore, CPT decreased the CD24-/lowCD44+ cell population in MCF7-TAMR cell-derived microspheres. Western blot results showed that CPT effectively inhibited the phosphorylation of estrogen receptor α (ER-α), and reduced the expression of phosphatidylinositol 3-kinase (PI3K-p85), serine-threonine protein kinase (Akt) and multidrug transporter ATP-binding cassette superfamily G member 2 (ABCG2). These results showed that CPT can induce cell apoptosis, cause cell cycle arrest, inhibit cell migration and inhibit ER-α phosphorylation, inhibit PI3K/Akt signaling pathway, reduce the number of CD24-/lowCD44+ cells and the expression of ABCG2, overcome cell drug resistance.

cryptotanshinone  /  breast cancer  /  tamoxifen-resistant cell  /  apoptosis  /  mechanism of action
刘航, 夏丽洁, 李金耀, 张英. 隐丹参酮对乳腺癌他莫昔芬耐药细胞的生长抑制作用与机制研究. 药学学报, 2022 , 57 (9) : 2751 -2758 . DOI: 10.16438/j.0513-4870.2022-0348
Hang LIU, Li-jie XIA, Jin-yao LI, Ying ZHANG. Inhibitory effects and mechanisms of cryptotanshinone on the growth of tamoxifen resistant breast cancer cells[J]. Acta Pharmaceutica Sinica, 2022 , 57 (9) : 2751 -2758 . DOI: 10.16438/j.0513-4870.2022-0348
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Year 2022 volume 57 Issue 9
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Article Info
doi: 10.16438/j.0513-4870.2022-0348
  • Receive Date：2022-03-24
  • Online Date：2025-12-24
  • Published：2022-09-12
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History
  • Received：2022-03-24
  • Revised：2022-05-13
Funding
Affiliations
    1. Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China
    2. Guang'anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing 100053, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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