Home Journals Articles Updates About
CN
image
收藏切换
Inhibitory effects and mechanisms of cryptotanshinone on the growth of tamoxifen resistant breast cancer cells
收藏切换
PDF
Hang LIU1, Li-jie XIA1, Jin-yao LI1, *, Ying ZHANG2, *
Acta Pharmaceutica Sinica | 2022, 57(9) : 2751 - 2758
Less
收藏切换
Acta Pharmaceutica Sinica | 2022, 57(9): 2751-2758
• Original Articles •
Inhibitory effects and mechanisms of cryptotanshinone on the growth of tamoxifen resistant breast cancer cells
Full
Hang LIU1, Li-jie XIA1, Jin-yao LI1, *, Ying ZHANG2, *
Affiliations
  • 1. Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China
  • 2. Guang'anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing 100053, China
Published: 2022-09-12 doi: 10.16438/j.0513-4870.2022-0348
Outline
收藏切换

This study investigated the inhibitory effect and mechanisms of cryptotanshinone (CPT) on tamoxifen resistant cell MCF7-TAMR. The inhibitory effect of CPT on the viability of MCF7-TAMR cells was evaluated using the MTT assay. We found that CPT significantly inhibited the growth of MCF7-TAMR cells in a dose- and time-dependent manner. The half inhibitory concentration (IC50) is 15.14 ± 2.82 μmol·L-1 at 24 h. CPT induced cell cycle arrest of MCF7-TAMR cells at G0/G1 phase, and promoted apoptosis of MCF7-TAMR cells by upregulating intracellular levels of reactive oxygen species (ROS). Transwell results showed that CPT significantly inhibited the migration of MCF7-TAMR cells. Furthermore, CPT decreased the CD24-/lowCD44+ cell population in MCF7-TAMR cell-derived microspheres. Western blot results showed that CPT effectively inhibited the phosphorylation of estrogen receptor α (ER-α), and reduced the expression of phosphatidylinositol 3-kinase (PI3K-p85), serine-threonine protein kinase (Akt) and multidrug transporter ATP-binding cassette superfamily G member 2 (ABCG2). These results showed that CPT can induce cell apoptosis, cause cell cycle arrest, inhibit cell migration and inhibit ER-α phosphorylation, inhibit PI3K/Akt signaling pathway, reduce the number of CD24-/lowCD44+ cells and the expression of ABCG2, overcome cell drug resistance.

cryptotanshinone  /  breast cancer  /  tamoxifen-resistant cell  /  apoptosis  /  mechanism of action
Hang LIU, Li-jie XIA, Jin-yao LI, Ying ZHANG. Inhibitory effects and mechanisms of cryptotanshinone on the growth of tamoxifen resistant breast cancer cells[J]. Acta Pharmaceutica Sinica, 2022 , 57 (9) : 2751 -2758 . DOI: 10.16438/j.0513-4870.2022-0348
Appendix
Less
Year 2022 volume 57 Issue 9
PDF
126
43
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2022-0348
  • Receive Date：2022-03-24
  • Online Date：2025-12-24
  • Published：2022-09-12
Article Data
Affiliations
History
  • Received：2022-03-24
  • Revised：2022-05-13
Funding
Affiliations
    1. Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China
    2. Guang'anmen Hospital, China Academy of Traditional Chinese Medicine, Beijing 100053, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2022-0348
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House