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Analysis of flavonoids and phenylethanoid glycosides in the Tibetan herb Lagotis brevituba Maxim based on UHPLC-LTQ-orbitrap-MS
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Zhao GENG1, 3, Bi-xing GAO1, 2, Lian ZHONG1, 2, Jing-liang QI2, Yan GOU1, *, Yun-bin JIANG4, *, Lei YANG1, Jun YUAN1, Li GUO2, Yi-tao WANG3
Acta Pharmaceutica Sinica | 2022, 57(9) : 2821 - 2838
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Acta Pharmaceutica Sinica | 2022, 57(9): 2821-2838
• Original Articles •
Analysis of flavonoids and phenylethanoid glycosides in the Tibetan herb Lagotis brevituba Maxim based on UHPLC-LTQ-orbitrap-MS
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Zhao GENG1, 3, Bi-xing GAO1, 2, Lian ZHONG1, 2, Jing-liang QI2, Yan GOU1, *, Yun-bin JIANG4, *, Lei YANG1, Jun YUAN1, Li GUO2, Yi-tao WANG3
Affiliations
  • 1. NMPA Key Laboratory for Quality Evaluation of Traditional Chinese Medicine (Traditional Chinese Patent Medicine), Sichuan Institute for Drug Control (Sichuan Testing Center of Medical Devices), Chengdu 611731, China
  • 2. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
  • 3. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
  • 4. College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China
Published: 2022-09-12 doi: 10.16438/j.0513-4870.2022-0504
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Ultra high performance liquid chromatography tandem linear ion trap orbitrap mass spectrometry (UHPLC-LTQ-orbitrap-MS) was applied to analyze and identify flavonoids and phenylethanoid glycosides in the Tibetan herb Lagotis brevituba Maxim. A method of data-dependent scan coupling with dynamic exclusion was developed for analyzing flavonoids and phenylethanoid glycosides under positive and negative ion mode of electrospray ionization (ESI). The compounds of Lagotis brevituba Maxim. were systematically identified through exact molecular mass, fragmentation patterns, retention time and reported references. A total of 167 compounds were detected, of which 84 were flavonoids and 83 were phenylethanoid glycosides, which greatly enriched the number and types of flavonoids and phenylethanol glycosides in Lagotis genus medicinal plants. Baohuoside Ⅰ, 4 disaccharide O-glycoside flavonoids (composed of deoxyhexose and glucuronic acid), 9 C-glycoside flavonoids, 15 tetrasaccharide phenylethanoid glycosides and 5 phenylethanoid glycosides with substituents on the β-position of the phenylethyl group were identified in Lagotis genus medicinal plants for the first time. This study provides scientific support for elucidating the material basis and improving the quality control of Lagotis brevituba Maxim.

Lagotis brevituba Maxim.  /  UHPLC-LTQ-orbitrap-MS  /  flavonoid  /  phenylethanoid glycoside  /  Lagotis genus
Zhao GENG, Bi-xing GAO, Lian ZHONG, Jing-liang QI, Yan GOU, Yun-bin JIANG, Lei YANG, Jun YUAN, Li GUO, Yi-tao WANG. Analysis of flavonoids and phenylethanoid glycosides in the Tibetan herb Lagotis brevituba Maxim based on UHPLC-LTQ-orbitrap-MS[J]. Acta Pharmaceutica Sinica, 2022 , 57 (9) : 2821 -2838 . DOI: 10.16438/j.0513-4870.2022-0504
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Article Info
doi: 10.16438/j.0513-4870.2022-0504
  • Receive Date：2022-04-27
  • Online Date：2025-12-24
  • Published：2022-09-12
Article Data
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History
  • Received：2022-04-27
  • Revised：2022-06-22
Funding
Affiliations
    1. NMPA Key Laboratory for Quality Evaluation of Traditional Chinese Medicine (Traditional Chinese Patent Medicine), Sichuan Institute for Drug Control (Sichuan Testing Center of Medical Devices), Chengdu 611731, China
    2. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
    3. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
    4. College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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