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Mechanistic understanding of the inhibitory effect of cytochrome P450 3A4 and 3A5 by Wuzhi tablet (Schisandra sphenanthera extract)
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Xiao-ling QIN1, Wen-hai DUAN1, Jia-li LI2, Min HUANG2, Hui-chang BI3, *
Acta Pharmaceutica Sinica | 2022, 57(8) : 2453 - 2460
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Acta Pharmaceutica Sinica | 2022, 57(8): 2453-2460
• Original Articles •
Mechanistic understanding of the inhibitory effect of cytochrome P450 3A4 and 3A5 by Wuzhi tablet (Schisandra sphenanthera extract)
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Xiao-ling QIN1, Wen-hai DUAN1, Jia-li LI2, Min HUANG2, Hui-chang BI3, *
Affiliations
  • 1. Guangdong Food and Drug Vocational College, Guangzhou 510520, China
  • 2. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
  • 3. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
Published: 2022-08-12 doi: 10.16438/j.0513-4870.2022-0651
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Wuzhi tablet (WZ) is a prescribed herbal medicine extracted from Schisandra sphenanthera, which is widely used to protect the liver injury and drug-induced hepatotoxicity in clinical practices. Previous studies showed that WZ significantly increased the blood concentrations of tacrolimus, cyclosporine A, paclitaxel by inhibiting the cytochrome P450 3A (CYP3A)-mediated metabolism. CYP3A4 and CYP3A5 are the most important isoenzymes among the CYP3A subfamily. However, there are some differences in the catalytic and inhibitory activities between CYP3A4 and CYP3A5, which may lead to different risk of drug-drug and herb-drug interactions, and the risks may be further amplified in vivo. Currently, few reports have compared the herbal medicine inhibitory effects between CYP3A4 and CYP3A5 mediated metabolic reactions. Therefore, detailing the inhibitory effect of WZ on CYP3A4 and CYP3A5 will help understand and predict the potential herb-drug interaction. The results showed that WZ inhibited CYP3A4 and CYP3A5 in a NADPH-, time- and concentration- dependent manner. WZ showed more potent inhibition on CYP3A5 than CYP3A4. Cautions warranted when combining WZ with other therapeutic drugs to avoid the potential herb-drug interaction.

Wuzhi tablet  /  Schisandra sphenanthera  /  CYP3A4  /  CYP3A5  /  herb-drug interaction
Xiao-ling QIN, Wen-hai DUAN, Jia-li LI, Min HUANG, Hui-chang BI. Mechanistic understanding of the inhibitory effect of cytochrome P450 3A4 and 3A5 by Wuzhi tablet (Schisandra sphenanthera extract)[J]. Acta Pharmaceutica Sinica, 2022 , 57 (8) : 2453 -2460 . DOI: 10.16438/j.0513-4870.2022-0651
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Article Info
doi: 10.16438/j.0513-4870.2022-0651
  • Receive Date：2022-05-26
  • Online Date：2025-12-23
  • Published：2022-08-12
Article Data
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History
  • Received：2022-05-26
  • Revised：2022-06-18
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Affiliations
    1. Guangdong Food and Drug Vocational College, Guangzhou 510520, China
    2. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
    3. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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