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A new diphenyl butanedione from Astragalus membranaceus of northern Shanxi
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Xiao-jun YANG1, *, Chao WANG1, Yun-peng JIA1, Yue SUN1, Huo-bing REN2
Acta Pharmaceutica Sinica | 2022, 57(8) : 2430 - 2434
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Acta Pharmaceutica Sinica | 2022, 57(8): 2430-2434
• Original Articles •
A new diphenyl butanedione from Astragalus membranaceus of northern Shanxi
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Xiao-jun YANG1, *, Chao WANG1, Yun-peng JIA1, Yue SUN1, Huo-bing REN2
Affiliations
  • 1. College of Chemistry and Chemical Engineering, Yan′an University, Yan'an 716000, China
  • 2. Shaanxi Yuankang Traditional Chinese Medicine Industry Development Co., Ltd., Suide 718000, China
Published: 2022-08-12 doi: 10.16438/j.0513-4870.2022-0148
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Seven compounds were isolated from Astragalus membranaceus of northern shaanxi by silica gel and Sephadex LH-20 column chromatographies. Their chemical structures were identified on the basis of their physical and chemical properties. These compounds were elucidated as astragaloside Ⅳ (1), formononetin (2), calycosin (3), 1-(4-hydroxyphenyl)-4-(2, 4-hydroxyphenyl)-2-hydroxy-1, 4-but anedione (4), (E)-4-methylcinnamic acid (5), quercetin (6), and uridine (7). Compound 4 is a new compound and compound 5 was isolated from the plants of Astragalus Linn. for the first time. The results of in vitro antitumor activity assay showed that compound 4 could inhibit the proliferation of A549 with IC50 values of 11.41 μmol·L-1.

Astragalus membranaceus (Fisch.) Bge.  /  chemical constituent  /  diphenyl butanedione  /  antitumor activity
Xiao-jun YANG, Chao WANG, Yun-peng JIA, Yue SUN, Huo-bing REN. A new diphenyl butanedione from Astragalus membranaceus of northern Shanxi[J]. Acta Pharmaceutica Sinica, 2022 , 57 (8) : 2430 -2434 . DOI: 10.16438/j.0513-4870.2022-0148
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Article Info
doi: 10.16438/j.0513-4870.2022-0148
  • Receive Date：2022-02-08
  • Online Date：2025-12-23
  • Published：2022-08-12
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  • Received：2022-02-08
  • Revised：2022-03-14
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    1. College of Chemistry and Chemical Engineering, Yan′an University, Yan'an 716000, China
    2. Shaanxi Yuankang Traditional Chinese Medicine Industry Development Co., Ltd., Suide 718000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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