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Research progress of nano delivery system in mRNA tumor vaccines
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Pan-pan GU, Tong GAO, Yong-jun LIU*, Na ZHANG*
Acta Pharmaceutica Sinica | 2022, 57(8) : 2327 - 2333
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Acta Pharmaceutica Sinica | 2022, 57(8): 2327-2333
• Reviews •
Research progress of nano delivery system in mRNA tumor vaccines
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Pan-pan GU, Tong GAO, Yong-jun LIU*, Na ZHANG*
Affiliations
  • Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
Published: 2022-08-12 doi: 10.16438/j.0513-4870.2022-0363
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Tumor vaccine is one of the most promising therapeutic strategies in tumor immunotherapy. It promotes the antigen presentation process by delivering tumor antigen and then activates the anti-tumor immune response. As a new class of vaccines, messenger RNA (mRNA) vaccines can activate the immune system to achieve the purpose of immunotherapy by delivering the mRNA sequence of a specific antigen into the body and expressing the corresponding antigen protein. Compared with traditional vaccines, mRNA vaccines have the advantages of a short production cycle, high effectiveness, and strong immunogenicity. In recent years, the application of mRNA vaccines in tumor immunotherapy has attracted widespread attention, but the instability and low delivery efficiency of mRNA limit its application. Nano delivery system can effectively solve the problem of mRNA vaccine delivery, greatly promote the research process and clinical application of mRNA tumor vaccines, and has become a hot spot in the research of mRNA vaccines. In this review, we introduced the mRNA tumor vaccines, focusing on the application of nano delivery system in mRNA tumor vaccines, in order to provide new ideas and new methods for the efficient delivery of mRNA tumor vaccines and tumor immunotherapy.

mRNA vaccine  /  tumor vaccine  /  nano delivery system  /  tumor treatment  /  immunotherapy
Pan-pan GU, Tong GAO, Yong-jun LIU, Na ZHANG. Research progress of nano delivery system in mRNA tumor vaccines[J]. Acta Pharmaceutica Sinica, 2022 , 57 (8) : 2327 -2333 . DOI: 10.16438/j.0513-4870.2022-0363
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Year 2022 volume 57 Issue 8
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doi: 10.16438/j.0513-4870.2022-0363
  • Receive Date：2022-03-28
  • Online Date：2025-12-23
  • Published：2022-08-12
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  • Received：2022-03-28
  • Revised：2022-04-28
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    Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
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小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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