Home Journals Articles Updates About
CN
image
收藏切换
Research advances of small molecule inhibitors in the treatment of mixed lineage leukemia
收藏切换
PDF
Meng-lan LUO1, 2, Yu-ting CHEN2, Tong-chao LIU2, Yong-mei CUI*, 1, Dan-qi CHEN*, 2, Bing XIONG*, 2
Acta Pharmaceutica Sinica | 2022, 57(8) : 2292 - 2312
Less
收藏切换
Acta Pharmaceutica Sinica | 2022, 57(8): 2292-2312
• Reviews •
Research advances of small molecule inhibitors in the treatment of mixed lineage leukemia
Full
Meng-lan LUO1, 2, Yu-ting CHEN2, Tong-chao LIU2, Yong-mei CUI*, 1, Dan-qi CHEN*, 2, Bing XIONG*, 2
Affiliations
  • 1. College of Sciences, Shanghai University, Shanghai 200444, China
  • 2. University of Chinese Academy of Sciences, Chinese Academy of Sciences Shanghai Institute of Materia Medica, Shanghai 201203, China
Published: 2022-08-12 doi: 10.16438/j.0513-4870.2022-0236
Outline
收藏切换

Acute leukemia (AL) is a kind of malignant clonal disease of hematopoietic stem cells. Rearrangement of mixed lineage leukemia (MLL) gene can be observed in about 5%-10% of AL patients. Currently, AL patients with MLL-rearrangements (MLL-r) lack effective treatment and are usually associated with poor prognoses. Recent studies have shown that many epigenetic regulators are directly or indirectly involved in the occurrence and development of AL carrying MLL-r (MLL), which provides a biological basis for the use of epigenetic regulation strategies to treat MLL. In this review, we start from the epigenetic regulation mechanism of MLL, and select representative drug targets to briefly analyze the relationship between each target and MLL and summarize the development progress of their inhibitors, hoping to provide reference for the subsequent research and development of drugs for the treatment of MLL.

mixed lineage leukemia  /  mixed lineage leukemia fusion protein  /  epigenetic regulator  /  inhibitor
Meng-lan LUO, Yu-ting CHEN, Tong-chao LIU, Yong-mei CUI, Dan-qi CHEN, Bing XIONG. Research advances of small molecule inhibitors in the treatment of mixed lineage leukemia[J]. Acta Pharmaceutica Sinica, 2022 , 57 (8) : 2292 -2312 . DOI: 10.16438/j.0513-4870.2022-0236
Appendix
Less
Year 2022 volume 57 Issue 8
PDF
161
67
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2022-0236
  • Receive Date：2022-02-24
  • Online Date：2025-12-23
  • Published：2022-08-12
Article Data
Affiliations
History
  • Received：2022-02-24
  • Revised：2022-03-15
Funding
Affiliations
    1. College of Sciences, Shanghai University, Shanghai 200444, China
    2. University of Chinese Academy of Sciences, Chinese Academy of Sciences Shanghai Institute of Materia Medica, Shanghai 201203, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2022-0236
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House