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A new flavone glycoside from Eriocaulon buergerianum
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Yong ZHANG1, 2, 3, Akber Aisa HAJI1, 3, Wei-liang ZHU1, 2, 3, *
Acta Pharmaceutica Sinica | 2022, 57(7) : 2139 - 2145
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Acta Pharmaceutica Sinica | 2022, 57(7): 2139-2145
• Original Articles •
A new flavone glycoside from Eriocaulon buergerianum
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Yong ZHANG1, 2, 3, Akber Aisa HAJI1, 3, Wei-liang ZHU1, 2, 3, *
Affiliations
  • 1. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, CAS Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China
  • 2. CAS Key Laboratory of Receptor Research, Stake Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • 3. University of Chinese Academy of Sciences, Beijing 100049, China
Published: 2022-07-12 doi: 10.16438/j.0513-4870.2022-0133
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Ten compounds were isolated from the water extract of Eriocaulon buergerianum by HP20, ODS, Sephadex LH-20 and MCI Gel CHP-20 column chromatographic methods. Their structures were identified by spectroscopic and chemical approaches as 6-methoxyquercetin-3-O-(2'''-vanilloyl)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (1), syringaresinol-4'-O-β-D-glucopyranoside (2), rutin (3), 1-O-feruloylglycerol (4), 1, 2-benzenediol (5), vomifoliol (6), β-D-(6-O-trans-feruloyl) fructofuranosyl-α-D-O-glucopyranosied (7), dihydroferulic acid (8), guanosine (9) and quercetin-3-O-β-gentiobioside (10). The compound 1 is a new compound, the compounds 2 and 4-10 were obtained from Eriocaulon genus for the first time, and the compound 3 was isolated from this plant for the first time. Molecular docking study showed that 1 is a potential inhibitor of TNF-α. The compound 1 was evaluated for their anti-inflammatory activities in vitro, and 1 showed significant inhibitory activity against TNF-α production in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells at the concentrations of 1, 10 and 100 μmol·L-1.

Eriocaulon Linn.  /  Eriocaulon buergerianum Koern.  /  flavone glycoside  /  chemical constituent  /  anti-inflammatory
Yong ZHANG, Akber Aisa HAJI, Wei-liang ZHU. A new flavone glycoside from Eriocaulon buergerianum[J]. Acta Pharmaceutica Sinica, 2022 , 57 (7) : 2139 -2145 . DOI: 10.16438/j.0513-4870.2022-0133
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Year 2022 volume 57 Issue 7
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Article Info
doi: 10.16438/j.0513-4870.2022-0133
  • Receive Date：2022-01-28
  • Online Date：2025-12-23
  • Published：2022-07-12
Article Data
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History
  • Received：2022-01-28
  • Revised：2022-03-08
Funding
Affiliations
    1. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, CAS Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China
    2. CAS Key Laboratory of Receptor Research, Stake Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    3. University of Chinese Academy of Sciences, Beijing 100049, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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