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Evaluation on the efficacy of moxifloxacin hydrochloride based on physiological pharmacokinetic models
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Jie GAO1, 2, Fang FENG2, Li-xin WANG1, Xiao-meng CHONG1, Chen WANG1, *, Li-hui YIN1, *
Acta Pharmaceutica Sinica | 2022, 57(7) : 2153 - 2157
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Acta Pharmaceutica Sinica | 2022, 57(7): 2153-2157
• Original Articles •
Evaluation on the efficacy of moxifloxacin hydrochloride based on physiological pharmacokinetic models
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Jie GAO1, 2, Fang FENG2, Li-xin WANG1, Xiao-meng CHONG1, Chen WANG1, *, Li-hui YIN1, *
Affiliations
  • 1. National Institutes for Food and Drug Control, Beijing 102629, China
  • 2. China Pharmaceutical University, Nanjing 210009, China
Published: 2022-07-12 doi: 10.16438/j.0513-4870.2022-0108
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This study is to establish and validation in vivo models of moxifloxacin based on the theory of physiologically based pharmacokinetics (PBPK), and then to predict the distribution of moxifloxacin in human venous return and organ such as lung, spleen and so on. The efficacy of moxifloxacin and its pharmaceutical preparations were quantified by comparing the pharmacokinetic parameters with the minimum inhibitory concentration of related pathogenic bacterium. The results showed that the anti-infection efficacy of pharmaceutical moxifloxacin preparation in the corresponding organs was basically the same. The PBPK model of moxifloxacin preparations can be more accurately described the pharmacokinetic of anti-infective drugs in human, it is suitable for the efficacy evaluation of anti-infective drugs and provides a strong basis for the corresponding scientific research and scientific supervision.

moxifloxacin hydrochloride  /  physiologically based pharmacokinetic model  /  efficacy  /  pharmacodynamics
Jie GAO, Fang FENG, Li-xin WANG, Xiao-meng CHONG, Chen WANG, Li-hui YIN. Evaluation on the efficacy of moxifloxacin hydrochloride based on physiological pharmacokinetic models[J]. Acta Pharmaceutica Sinica, 2022 , 57 (7) : 2153 -2157 . DOI: 10.16438/j.0513-4870.2022-0108
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Article Info
doi: 10.16438/j.0513-4870.2022-0108
  • Receive Date：2022-01-25
  • Online Date：2025-12-23
  • Published：2022-07-12
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History
  • Received：2022-01-25
  • Revised：2022-05-10
Affiliations
    1. National Institutes for Food and Drug Control, Beijing 102629, China
    2. China Pharmaceutical University, Nanjing 210009, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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