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Advances in the study of structural modification and biological activities of asiatic acid
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Bin LIU1, 2, Wen-qiang TANG1, 2, Hong-juan TONG1, 2, Zhou-jing ZHU1, 2, Chu TANG3, *
Acta Pharmaceutica Sinica | 2022, 57(7) : 1962 - 1976
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Acta Pharmaceutica Sinica | 2022, 57(7): 1962-1976
• Reviews •
Advances in the study of structural modification and biological activities of asiatic acid
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Bin LIU1, 2, Wen-qiang TANG1, 2, Hong-juan TONG1, 2, Zhou-jing ZHU1, 2, Chu TANG3, *
Affiliations
  • 1. School of Pharmacy, Shaanxi Institute of International Trade & Commerce, Xianyang 712046, China
  • 2. Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province, Xianyang 712046, China
  • 3. School of Life Science and Technology, Xidian University, Xi'an 710126, China
Published: 2022-07-12 doi: 10.16438/j.0513-4870.2022-0073
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Asiatic acid (AA) is a ursane pentacyclic triterpenoids, which possesses a wide range of pharmacological activities, such as anti-tumor, hypoglycemic, anti-inflammatory, anti-bacterial. Due to poor solubility and low bioavailability, clinical application of asiatic acid is limited. To address these defects, the structural modifications of AA have been carried out, and large numbers of AA-based derivatives with novel structure and eximious biological activity have been developed. In this paper, the research progress of structural modifications, biological activity, structure-activity relationship and mechanism studies in recent twenty years are reviewed, which provides reference for development of AA-related drugs.

asiatic acid  /  derivative  /  structural modification  /  biological activity  /  structure-activity relationship
Bin LIU, Wen-qiang TANG, Hong-juan TONG, Zhou-jing ZHU, Chu TANG. Advances in the study of structural modification and biological activities of asiatic acid[J]. Acta Pharmaceutica Sinica, 2022 , 57 (7) : 1962 -1976 . DOI: 10.16438/j.0513-4870.2022-0073
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Article Info
doi: 10.16438/j.0513-4870.2022-0073
  • Receive Date：2022-01-14
  • Online Date：2025-12-23
  • Published：2022-07-12
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History
  • Received：2022-01-14
  • Revised：2022-02-18
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Affiliations
    1. School of Pharmacy, Shaanxi Institute of International Trade & Commerce, Xianyang 712046, China
    2. Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province, Xianyang 712046, China
    3. School of Life Science and Technology, Xidian University, Xi'an 710126, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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