Home Journals Articles Updates About
CN
image
收藏切换
Effect of Qinggan Xiefei Fang on increasing susceptibility of influenza virus caused by "liver fire invading lung"
收藏切换
PDF
Yu-hui LU1, 2, 3, Shu-hua OUYANG1, 2, 3, Jing-yu WENG1, 2, 3, Pei LIU1, 4, Xin-xing CHEN1, 2, 3, Kurihara HIROSHI1, 2, 3, Yi-fang LI1, 2, 3, *, Rong-rong HE1, 2, 3
Acta Pharmaceutica Sinica | 2022, 57(6) : 1649 - 1656
Less
收藏切换
Acta Pharmaceutica Sinica | 2022, 57(6): 1649-1656
• Special Reports: Oxidative Stress in Physiopathology and Pharmacological Treatment •
Effect of Qinggan Xiefei Fang on increasing susceptibility of influenza virus caused by "liver fire invading lung"
Full
Yu-hui LU1, 2, 3, Shu-hua OUYANG1, 2, 3, Jing-yu WENG1, 2, 3, Pei LIU1, 4, Xin-xing CHEN1, 2, 3, Kurihara HIROSHI1, 2, 3, Yi-fang LI1, 2, 3, *, Rong-rong HE1, 2, 3
Affiliations
  • 1. Guangdong Engineering Research Center of Chinese Medicine and Disease Susceptibility, Jinan University, Guangzhou 510632, China
  • 2. Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China
  • 3. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China
  • 4. School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China
Published: 2022-06-12 doi: 10.16438/j.0513-4870.2022-0254
Outline
收藏切换

In this study, chronic emotional stress-induced H1N1 influenza susceptibility model was employed to simulate the states of "emotional stagnation" and "liver fire invading lung", and the protective effect of Qinggan Xiefei Fang on viral pneumonia was investigated. Survival rate and morbidity rate of mice were observed within 21 days after H1N1 infection, the symptoms of viral pneumonia and the level of phospholipid peroxidation were detected in lungs of mice after 6-day infection. The experimental results showed that Qinggan Xiefei Fang could alleviate the decline of survival rate and morbidity rate of mice caused by chronic constraint stress loaded with H1N1, inhibit the replication of H1N1 and the production of inflammatory factors, reduce the level of phospholipid peroxidation, and improve the symptoms of pneumonia in mice. The results also showed that compound-target network of Qinggan Xiefei Fang contained 171 compounds and 260 corresponding targets involved in the signaling pathway of oxidative stress, inflammation and immunity. All the above results indicate that Qinggan Xiefei Fang protecting influenza virus pneumonia was related to the regulation of oxidative stress. The animal experimental protocol has been reviewed and approved by Laboratory Animal Ethics Committee of Jinan University, in compliance with the Institutional Animal Care Guidelines.

emotional stress  /  Qinggan Xiefei Fang  /  influenza viral pneumonia  /  oxidative stress  /  phospholipid peroxidation
Yu-hui LU, Shu-hua OUYANG, Jing-yu WENG, Pei LIU, Xin-xing CHEN, Kurihara HIROSHI, Yi-fang LI, Rong-rong HE. Effect of Qinggan Xiefei Fang on increasing susceptibility of influenza virus caused by "liver fire invading lung"[J]. Acta Pharmaceutica Sinica, 2022 , 57 (6) : 1649 -1656 . DOI: 10.16438/j.0513-4870.2022-0254
Appendix
Less
Year 2022 volume 57 Issue 6
PDF
148
56
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2022-0254
  • Receive Date：2022-02-25
  • Online Date：2025-12-23
  • Published：2022-06-12
Article Data
Affiliations
History
  • Received：2022-02-25
  • Revised：2022-03-30
Funding
Affiliations
    1. Guangdong Engineering Research Center of Chinese Medicine and Disease Susceptibility, Jinan University, Guangzhou 510632, China
    2. Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China
    3. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China
    4. School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2022-0254
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House