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Effect of Qinggan Xiefei Fang on increasing susceptibility of influenza virus caused by "liver fire invading lung"
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Yu-hui LU1, 2, 3, Shu-hua OUYANG1, 2, 3, Jing-yu WENG1, 2, 3, Pei LIU1, 4, Xin-xing CHEN1, 2, 3, Kurihara HIROSHI1, 2, 3, Yi-fang LI1, 2, 3, *, Rong-rong HE1, 2, 3
Acta Pharmaceutica Sinica | 2022, 57(6) : 1649 - 1656
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Acta Pharmaceutica Sinica | 2022, 57(6): 1649-1656
• Special Reports: Oxidative Stress in Physiopathology and Pharmacological Treatment •
Effect of Qinggan Xiefei Fang on increasing susceptibility of influenza virus caused by "liver fire invading lung"
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Yu-hui LU1, 2, 3, Shu-hua OUYANG1, 2, 3, Jing-yu WENG1, 2, 3, Pei LIU1, 4, Xin-xing CHEN1, 2, 3, Kurihara HIROSHI1, 2, 3, Yi-fang LI1, 2, 3, *, Rong-rong HE1, 2, 3
Affiliations
  • 1. Guangdong Engineering Research Center of Chinese Medicine and Disease Susceptibility, Jinan University, Guangzhou 510632, China
  • 2. Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China
  • 3. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China
  • 4. School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China
Published: 2022-06-12 doi: 10.16438/j.0513-4870.2022-0254
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In this study, chronic emotional stress-induced H1N1 influenza susceptibility model was employed to simulate the states of "emotional stagnation" and "liver fire invading lung", and the protective effect of Qinggan Xiefei Fang on viral pneumonia was investigated. Survival rate and morbidity rate of mice were observed within 21 days after H1N1 infection, the symptoms of viral pneumonia and the level of phospholipid peroxidation were detected in lungs of mice after 6-day infection. The experimental results showed that Qinggan Xiefei Fang could alleviate the decline of survival rate and morbidity rate of mice caused by chronic constraint stress loaded with H1N1, inhibit the replication of H1N1 and the production of inflammatory factors, reduce the level of phospholipid peroxidation, and improve the symptoms of pneumonia in mice. The results also showed that compound-target network of Qinggan Xiefei Fang contained 171 compounds and 260 corresponding targets involved in the signaling pathway of oxidative stress, inflammation and immunity. All the above results indicate that Qinggan Xiefei Fang protecting influenza virus pneumonia was related to the regulation of oxidative stress. The animal experimental protocol has been reviewed and approved by Laboratory Animal Ethics Committee of Jinan University, in compliance with the Institutional Animal Care Guidelines.

emotional stress  /  Qinggan Xiefei Fang  /  influenza viral pneumonia  /  oxidative stress  /  phospholipid peroxidation
陆钰辉, 欧阳淑桦, 翁竞玉, 刘佩, 陈新星, 栗原博, 李怡芳, 何蓉蓉. 清肝泻肺方治疗肝火犯肺增加流感病毒易感性的作用研究. 药学学报, 2022 , 57 (6) : 1649 -1656 . DOI: 10.16438/j.0513-4870.2022-0254
Yu-hui LU, Shu-hua OUYANG, Jing-yu WENG, Pei LIU, Xin-xing CHEN, Kurihara HIROSHI, Yi-fang LI, Rong-rong HE. Effect of Qinggan Xiefei Fang on increasing susceptibility of influenza virus caused by "liver fire invading lung"[J]. Acta Pharmaceutica Sinica, 2022 , 57 (6) : 1649 -1656 . DOI: 10.16438/j.0513-4870.2022-0254
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Year 2022 volume 57 Issue 6
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Article Info
doi: 10.16438/j.0513-4870.2022-0254
  • Receive Date：2022-02-25
  • Online Date：2025-12-23
  • Published：2022-06-12
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History
  • Received：2022-02-25
  • Revised：2022-03-30
Funding
Affiliations
    1. Guangdong Engineering Research Center of Chinese Medicine and Disease Susceptibility, Jinan University, Guangzhou 510632, China
    2. Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China
    3. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China
    4. School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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