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A new nucleoside from the Oenothera biennis L.
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Juan-juan LIU1, 2, Jing-ke ZHANG1, 2, Qin-qin ZHANG1, 2, Meng LI1, 2, Deng-hui ZHU1, 2, Jun-jun WEI1, 2, Xiao-ke ZHENG1, 2, Wei-sheng FENG1, 2, *
Acta Pharmaceutica Sinica | 2022, 57(6) : 1840 - 1844
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Acta Pharmaceutica Sinica | 2022, 57(6): 1840-1844
• Original Articles •
A new nucleoside from the Oenothera biennis L.
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Juan-juan LIU1, 2, Jing-ke ZHANG1, 2, Qin-qin ZHANG1, 2, Meng LI1, 2, Deng-hui ZHU1, 2, Jun-jun WEI1, 2, Xiao-ke ZHENG1, 2, Wei-sheng FENG1, 2, *
Affiliations
  • 1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
Published: 2022-06-12 doi: 10.16438/j.0513-4870.2021-1735
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Seven nucleoside compounds were isolated from the Oenothera biennis L. by various chromatographic techniques such as Diaion HP-20, silica gel, Sephadex LH-20, MCI and semi-preparative HPLC. Their structures were identified by analysis of physicochemical properties and spectral data, and determined as 9-(3′-carbonyl methyl)hydroxypurine (1), 1-(3′-carbonyl methyl)purine-6, 8-dione (2), N-methyl-2-pyridone-5-carboxamide (3), uracil (4), uridine (5), thymidine (6) and 2′-Ο-methoxy luridine (7). Compound 1 is a new nucleoside and compounds 2-7 were newly isolated from the Oenothera biennis L. Compounds 1-2 can significantly increase the viability of BEAS-2B cells induced by TGF-β1, showing potent anti-pulmonary fibrosis activity.

Oenothera biennis L.  /  chemical constituent  /  nucleoside  /  BEAS-2B cell  /  MTT
Juan-juan LIU, Jing-ke ZHANG, Qin-qin ZHANG, Meng LI, Deng-hui ZHU, Jun-jun WEI, Xiao-ke ZHENG, Wei-sheng FENG. A new nucleoside from the Oenothera biennis L.[J]. Acta Pharmaceutica Sinica, 2022 , 57 (6) : 1840 -1844 . DOI: 10.16438/j.0513-4870.2021-1735
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Article Info
doi: 10.16438/j.0513-4870.2021-1735
  • Receive Date：2021-12-06
  • Online Date：2025-12-23
  • Published：2022-06-12
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  • Received：2021-12-06
  • Revised：2022-01-04
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    1. College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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