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Dynamic two-dimensional characterization technique and influencing factors analysis of the hygroscopicity of Chinese medicine extracts
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Ru-xi NING, Zhi-wei XIONG, Ying-xia ZHAO, Xiao-xin HU, Liang FENG*, Xiao-bin JIA*
Acta Pharmaceutica Sinica | 2022, 57(6) : 1887 - 1894
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Acta Pharmaceutica Sinica | 2022, 57(6): 1887-1894
Original Articles
Dynamic two-dimensional characterization technique and influencing factors analysis of the hygroscopicity of Chinese medicine extracts
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Ru-xi NING, Zhi-wei XIONG, Ying-xia ZHAO, Xiao-xin HU, Liang FENG*, Xiao-bin JIA*
Affiliations
  • School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Published: 2022-06-12 doi: 10.16438/j.0513-4870.2021-1277
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This study aims to construct a dynamic two-dimensional characterization technique for the hygroscopicity of traditional Chinese medicine extracts and investigate the effect of material properties of powders on hygroscopicity. The dynamic hygroscopicity-time curves of the powders were measured at 25 ℃ and 75% humidity, and the semi-equilibrium hygroscopicity time (t1/2) and equilibrium hygroscopicity (F) were derived as two-dimensional evaluation indicators. Finally, the correlation between the material properties and the hygroscopic behavior was analyzed by principal component analysis (PCA) and partial least squares analysis (PLS). The results showed that the dynamic two-dimensional characterization system of hygroscopicity constructed with 1/t1/2 = 0.1 h-1 and F = 15% as the center can classify the hygroscopic behavior of traditional Chinese medicine extracts into four categories: fast hygroscopicity with strong hygroscopicity, slow hygroscopicity with strong hygroscopicity, fast hygroscopicity with weak hygroscopicity and slow hygroscopicity with weak hygroscopicity. The moisture absorption was negatively correlated with D50, D90, ρb and ρt; the moisture absorption rate was negatively correlated with D10, D50, D90, ρb, ρt, and positively correlated with moisture content. The hygroscopicity dynamic two-dimensional characterization indicators of Chinese medicine extracts (CMEs) constructed in this study matched with the physical properties. The method of dynamic multi-dimensional characterization technology is feasible and scientific, and the idea has strong promotional value.

Chinese medicine extract  /  hygroscopicity  /  dynamic two-dimensional characterization  /  correlation  /  physical property parameter
Ru-xi NING, Zhi-wei XIONG, Ying-xia ZHAO, Xiao-xin HU, Liang FENG, Xiao-bin JIA. Dynamic two-dimensional characterization technique and influencing factors analysis of the hygroscopicity of Chinese medicine extracts[J]. Acta Pharmaceutica Sinica, 2022 , 57 (6) : 1887 -1894 . DOI: 10.16438/j.0513-4870.2021-1277
Year 2022 volume 57 Issue 6
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doi: 10.16438/j.0513-4870.2021-1277
  • Receive Date:2021-09-02
  • Online Date:2025-12-23
  • Published:2022-06-12
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  • Received:2021-09-02
  • Revised:2021-10-20
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    School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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