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Research progress of powder modification of TCM based on particle design theory
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Wei-feng ZHU1, Fu-cai CHEN1, Wen-jun LIU2, Liang-shan MING1, *, Yong-mei GUAN1, Li-hua CHEN1, Zhe LI1, *
Acta Pharmaceutica Sinica | 2022, 57(6) : 1781 - 1791
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Acta Pharmaceutica Sinica | 2022, 57(6): 1781-1791
• Reviews •
Research progress of powder modification of TCM based on particle design theory
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Wei-feng ZHU1, Fu-cai CHEN1, Wen-jun LIU2, Liang-shan MING1, *, Yong-mei GUAN1, Li-hua CHEN1, Zhe LI1, *
Affiliations
  • 1. Key Laboratory of Modern Preparation of TCM, Ministry of Education, Institute for Advanced Study, Research Center for Differentiation and Development of TCM Basic Theory, Jiangxi University of Chinese Medicine, Nanchang 330004, China
  • 2. Jiangzhong Pharmaceutical Co. Ltd., Nanchang 330049, China
Published: 2022-06-12 doi: 10.16438/j.0513-4870.2021-1469
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Particle design, based on the concept of "quality by design", combines the elements of microbiology, formulation science, heat and mass transfer, solid state physics, powder science, and nanotechnology. It is widely used to develop particles with excellent functional properties. Without affecting the active ingredients, the modification technology of traditional Chinese medicine (TCM) powder based on particle design theory, could improve the flowability, tabletability, disintegration and dissolution behavior, hygroscopicity, wettability, and other functional properties at the physical structure level. This greatly promotes the development of solid preparations of TCM. The present review aims to summarize and discuss the research progress of powder modification of TCM from the perspective of the theory of particle design, powder modification technology, equipment used for powder modification, application in TCM and modification mechanism mainly based on researches published in recent ten years. This review could provide ideas and theory basis for the development of particle design.

particle design  /  powder modification based on traditional Chinese medicine  /  theory of particle design  /  technology for powder modification  /  equipment for powder modification
Wei-feng ZHU, Fu-cai CHEN, Wen-jun LIU, Liang-shan MING, Yong-mei GUAN, Li-hua CHEN, Zhe LI. Research progress of powder modification of TCM based on particle design theory[J]. Acta Pharmaceutica Sinica, 2022 , 57 (6) : 1781 -1791 . DOI: 10.16438/j.0513-4870.2021-1469
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Article Info
doi: 10.16438/j.0513-4870.2021-1469
  • Receive Date：2021-10-12
  • Online Date：2025-12-23
  • Published：2022-06-12
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History
  • Received：2021-10-12
  • Revised：2021-11-26
Funding
Affiliations
    1. Key Laboratory of Modern Preparation of TCM, Ministry of Education, Institute for Advanced Study, Research Center for Differentiation and Development of TCM Basic Theory, Jiangxi University of Chinese Medicine, Nanchang 330004, China
    2. Jiangzhong Pharmaceutical Co. Ltd., Nanchang 330049, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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