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Progress on the protective effect of heme oxygenase-1 in viral infection
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Bai-he SUN, Yi-ting WANG, Yu-fei LU, Lin-lin MA*
Acta Pharmaceutica Sinica | 2022, 57(6) : 1574 - 1583
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Acta Pharmaceutica Sinica | 2022, 57(6): 1574-1583
• Special Reports: Oxidative Stress in Physiopathology and Pharmacological Treatment •
Progress on the protective effect of heme oxygenase-1 in viral infection
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Bai-he SUN, Yi-ting WANG, Yu-fei LU, Lin-lin MA*
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  • School of Medical Technology, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
Published: 2022-06-12 doi: 10.16438/j.0513-4870.2022-0265
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Heme oxygenase-1 (HO-1) is a cytoprotective enzyme that catalyzes the conversion of heme to CO, biliverdin, and iron, which together protect cells from oxidative and inflammatory damage and play an important role in maintaining cell homeostasis. In recent years, HO-1 has also been found to have antiviral biological effects, and the induced expression of HO-1 inhibits the replication of various viruses such as hepatitis C virus, hepatitis B virus, human immunodeficiency virus, dengue virus, ebolavirus, influenza A virus, Zika virus, severe acute respiratory syndrome coronavirus 2, human respiratory syncytial virus, hepatitis A virus and enterovirus 71. The inhibitory effect of HO-1 on these viruses involves three mechanisms, including direct inhibition of virus replication by HO-1 and its downstream products, enhancement of type I interferon responses in host cell, and attenuation of inflammatory damage caused by viral infection. This review focuses on the recent advances in the antiviral effect of HO-1 and its mechanism, which is expected to provide evidence for HO-1 as a potential target for antiviral therapy.

heme oxygenase-1  /  catalytic product  /  viral infection  /  type I interferon  /  inflammatory injury
Bai-he SUN, Yi-ting WANG, Yu-fei LU, Lin-lin MA. Progress on the protective effect of heme oxygenase-1 in viral infection[J]. Acta Pharmaceutica Sinica, 2022 , 57 (6) : 1574 -1583 . DOI: 10.16438/j.0513-4870.2022-0265
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Year 2022 volume 57 Issue 6
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doi: 10.16438/j.0513-4870.2022-0265
  • Receive Date：2022-03-01
  • Online Date：2025-12-23
  • Published：2022-06-12
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  • Received：2022-03-01
  • Revised：2022-04-18
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    School of Medical Technology, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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