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Ferroptosis of airway epithelial cells in asthma: current and future
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Xue-mei CHEN1, 2, Juan LIANG1, 2, Xiu-ling SONG1, 2, Xiao-hua LIU1, 2, Chu-peng XUE1, 2, Yu-ge HUANG1, Wen LI1, *
Acta Pharmaceutica Sinica | 2022, 57(6) : 1614 - 1620
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Acta Pharmaceutica Sinica | 2022, 57(6): 1614-1620
• Special Reports: Oxidative Stress in Physiopathology and Pharmacological Treatment •
Ferroptosis of airway epithelial cells in asthma: current and future
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Xue-mei CHEN1, 2, Juan LIANG1, 2, Xiu-ling SONG1, 2, Xiao-hua LIU1, 2, Chu-peng XUE1, 2, Yu-ge HUANG1, Wen LI1, *
Affiliations
  • 1. Department of Pediatric, the Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
  • 2. Graduate School of Guangdong Medical University, Zhanjiang 524001, China
Published: 2022-06-12 doi: 10.16438/j.0513-4870.2022-0079
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Ferroptosis is a novel cell death mode proposed in recent years, which is characterized by intracellular iron-dependent lipid peroxidation. Its mechanisms include lipid peroxidation, iron accumulation and the imbalance of antioxidant system. The crosstalk between ferroptosis and asthma is gradually deepening. Elucidating the specific mechanism of ferroptosis in regulating asthma is helpful to broaden the understanding of the pathology of asthma. This paper expounds the role of ferroptosis in airway epithelial cells in the occurrence and development of asthma from three perspectives: lipid peroxidation, iron accumulation and the imbalance of antioxidant system, hoping to find new targets and strategies for asthma treatment.

asthma  /  airway epithelial cell  /  ferroptosis  /  lipid peroxidation  /  iron  /  antioxidant system
Xue-mei CHEN, Juan LIANG, Xiu-ling SONG, Xiao-hua LIU, Chu-peng XUE, Yu-ge HUANG, Wen LI. Ferroptosis of airway epithelial cells in asthma: current and future[J]. Acta Pharmaceutica Sinica, 2022 , 57 (6) : 1614 -1620 . DOI: 10.16438/j.0513-4870.2022-0079
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Article Info
doi: 10.16438/j.0513-4870.2022-0079
  • Receive Date：2022-01-17
  • Online Date：2025-12-23
  • Published：2022-06-12
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History
  • Received：2022-01-17
  • Revised：2022-03-26
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Affiliations
    1. Department of Pediatric, the Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
    2. Graduate School of Guangdong Medical University, Zhanjiang 524001, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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