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Research progress on Fe-based metal-organic frameworks in antitumor drug delivery
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Hong GUO1, 2, Xia LI1, 2, Ding QU1, 2, Yan CHEN1, 2, *
Acta Pharmaceutica Sinica | 2022, 57(5) : 1252 - 1262
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Acta Pharmaceutica Sinica | 2022, 57(5): 1252-1262
• Reviews •
Research progress on Fe-based metal-organic frameworks in antitumor drug delivery
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Hong GUO1, 2, Xia LI1, 2, Ding QU1, 2, Yan CHEN1, 2, *
Affiliations
  • 1. Affiliated Hospital of Intergrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China
  • 2. Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China
Published: 2022-05-12 doi: 10.16438/j.0513-4870.2021-1263
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Fe-based metal-organic frameworks (MOFs) are a class of polymer crystals formed by the combination of Fe ions or Fe clusters with organic ligands through coordination bonds. At present, Fe-based MOFs can be mainly prepared by solvothermal synthesis, ultrasonic synthesis, microwave synthesis, and dry-gel conversion, etc. Fe-based MOFs have the characteristics of strong drug loading capacity of inorganic nano-carrier and high safety of organic nano-carrier, and have good tumor targeting and the capacity of inducting tumor's ferroptosis, which have high potential in the delivery of antitumor drugs. Recently, Fe-based MOFs have also been developed with various functions such as imaging, magnetic hyperthermia, photothermal therapy, photodynamic therapy, and intelligent response, which can facilitate diagnosis and monitor drug distribution while delivering antitumor drugs, and can produce synergistic antitumor effects combined with thermotherapy and phototherapy, and can also control the precise release of drugs. Reviewing the advances in the synthesis methods, characteristics as well as functions and types of Fe-based MOFs can provide a basis for the further applications of Fe-based MOFs in antitumor drug delivery.

Fe-based metal-organic framework  /  antitumor  /  drug delivery  /  nano  /  targeting
Hong GUO, Xia LI, Ding QU, Yan CHEN. Research progress on Fe-based metal-organic frameworks in antitumor drug delivery[J]. Acta Pharmaceutica Sinica, 2022 , 57 (5) : 1252 -1262 . DOI: 10.16438/j.0513-4870.2021-1263
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Article Info
doi: 10.16438/j.0513-4870.2021-1263
  • Receive Date：2021-08-31
  • Online Date：2025-12-23
  • Published：2022-05-12
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History
  • Received：2021-08-31
  • Revised：2021-09-28
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Affiliations
    1. Affiliated Hospital of Intergrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China
    2. Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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