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Profiling and characterization of the ingredients absorbed into blood and their metabolites of the Eucommiae Cortex extracts in rats with renal fibrosis induced by adenine based on UHPLC-Q-TOF-MS/MS
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Meng-qing WANG1, 2, Hui YU1, 2, Xin LIU1, 2, Jian-tao SONG1, 2, Hao CAI1, 2, *, Gang CAO3, Hui ZHU1, 2, Yu DUAN1, 2, Ke PEI4
Acta Pharmaceutica Sinica | 2022, 57(4) : 1136 - 1146
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Acta Pharmaceutica Sinica | 2022, 57(4): 1136-1146
• Original Articles •
Profiling and characterization of the ingredients absorbed into blood and their metabolites of the Eucommiae Cortex extracts in rats with renal fibrosis induced by adenine based on UHPLC-Q-TOF-MS/MS
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Meng-qing WANG1, 2, Hui YU1, 2, Xin LIU1, 2, Jian-tao SONG1, 2, Hao CAI1, 2, *, Gang CAO3, Hui ZHU1, 2, Yu DUAN1, 2, Ke PEI4
Affiliations
  • 1. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 2. Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 3. School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, China
  • 4. School of Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030619, China
Published: 2022-04-12 doi: 10.16438/j.0513-4870.2021-1790
Outline
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To profile and characterize the ingredients absorbed into blood and their metabolites of the Eucommiae Cortex (EC) extracts in rats with renal fibrosis induced by adenine, and so as to provide a reference for investigation of the pharmacodynamic substances of EC. SD rats with renal fibrosis induced by adenine were intragastrically administered with the EC extracts, and the rat plasma samples were collected and analyzed by UHPLC-Q-TOF-MS/MS to identify the prototype ingredients absorbed into blood and their metabolites. The experiment was approved by the experimental Animal Ethics Committee from Nanjing University of Chinese Medicine (No. 202103A008). The results showed that a total of 24 prototype compounds were identified, including 9 lignans, 4 iridoids, 8 phenylpropanoids, and 3 organic acids. Furthermore, 30 metabolites were obtained by further analysis, including 9 lignans, 19 iridoids, and 2 organic acids. The results of this study can provide the valuable reference for further elucidation of the pharmacodynamic substantial basis and mechanism of EC in the treatment of renal fibrosis.

Eucommiae Cortex  /  UHPLC-Q-TOF-MS/MS  /  ingredient absorbed into blood  /  metabolite  /  renal fibrosis
Meng-qing WANG, Hui YU, Xin LIU, Jian-tao SONG, Hao CAI, Gang CAO, Hui ZHU, Yu DUAN, Ke PEI. Profiling and characterization of the ingredients absorbed into blood and their metabolites of the Eucommiae Cortex extracts in rats with renal fibrosis induced by adenine based on UHPLC-Q-TOF-MS/MS[J]. Acta Pharmaceutica Sinica, 2022 , 57 (4) : 1136 -1146 . DOI: 10.16438/j.0513-4870.2021-1790
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Article Info
doi: 10.16438/j.0513-4870.2021-1790
  • Receive Date：2021-12-14
  • Online Date：2025-12-22
  • Published：2022-04-12
Article Data
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History
  • Received：2021-12-14
  • Revised：2022-01-06
Funding
Affiliations
    1. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
    2. Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210023, China
    3. School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, China
    4. School of Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Jinzhong 030619, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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