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Research progress on the changes and mechanism of intestinal drug transporters in inflammatory bowel disease
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Min-lei DONG1, Jun LUO1, Hui-di JIANG1, Ping LI1, 2, *
Acta Pharmaceutica Sinica | 2022, 57(4) : 943 - 951
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Acta Pharmaceutica Sinica | 2022, 57(4): 943-951
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Research progress on the changes and mechanism of intestinal drug transporters in inflammatory bowel disease
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Min-lei DONG1, Jun LUO1, Hui-di JIANG1, Ping LI1, 2, *
Affiliations
  • 1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
  • 2. Hangzhou First People's Hospital, Hangzhou 310006, China
Published: 2022-04-12 doi: 10.16438/j.0513-4870.2021-1214
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Inflammatory bowel disease (IBD) is a disease characterized by chronic and progressive inflammation of the intestinal tract, which seriously affects the quality of life of patients because it is difficult to cure and easy to recur. As the main organ of substance absorption, the changes of intestinal drug transporters will lead to changes in the behavior of endogenous and exogenous substances in vivo. Changes in the expression and function of a variety of drug transporters have also been observed in intestinal inflammatory tissues of patients with IBD. This paper reviews the changes of intestinal drug transporters in IBD and its related mechanisms, which provides a theoretical basis for finding new strategies for the treatment of IBD and clinical rational drug use.

inflammatory bowel disease  /  intestinal drug transporter  /  regulation  /  mechanism
Min-lei DONG, Jun LUO, Hui-di JIANG, Ping LI. Research progress on the changes and mechanism of intestinal drug transporters in inflammatory bowel disease[J]. Acta Pharmaceutica Sinica, 2022 , 57 (4) : 943 -951 . DOI: 10.16438/j.0513-4870.2021-1214
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Year 2022 volume 57 Issue 4
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Article Info
doi: 10.16438/j.0513-4870.2021-1214
  • Receive Date：2021-08-21
  • Online Date：2025-12-22
  • Published：2022-04-12
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History
  • Received：2021-08-21
  • Revised：2021-10-06
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Affiliations
    1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
    2. Hangzhou First People's Hospital, Hangzhou 310006, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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