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Applications of nanobodies in G protein-coupled receptors research
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Yi WANG, Yan-Jie ZHAO, Shuai LI*
Acta Pharmaceutica Sinica | 2022, 57(4) : 990 - 1001
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Acta Pharmaceutica Sinica | 2022, 57(4): 990-1001
• Reviews •
Applications of nanobodies in G protein-coupled receptors research
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Yi WANG, Yan-Jie ZHAO, Shuai LI*
Affiliations
  • Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin 300060, China
Published: 2022-04-12 doi: 10.16438/j.0513-4870.2021-1203
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G protein-coupled receptors (GPCRs), the largest family of transmembrane receptors in the human, contain seven transmembrane helices, and are usually regarded as critical drug targets because of their key roles in multiple diseases. Currently, 30%-40% approved drugs target GPCRs. Nanobodies (also known as single domain antibodies) are important research tools for GPCRs due to their small molecular weight, good biochemical properties and high affinity for "cracks or cavities". In addition, nanobodies have long complementarity determining region 3 (CDR3) loops which can be inserted deeply into GPCRs ligand binding pockets, efficiently binding to the folds. This review summarizes the characteristics of nanobodies and their applications in GPCRs research and briefly introduces the current identification routes of targeted GPCRs nanobodies, which could provide new idea and method for applications of nanobodies in GPCRs research.

G protein coupled receptor  /  single-domain antibody  /  nanobody  /  crystallization  /  chemotaxis
Yi WANG, Yan-Jie ZHAO, Shuai LI. Applications of nanobodies in G protein-coupled receptors research[J]. Acta Pharmaceutica Sinica, 2022 , 57 (4) : 990 -1001 . DOI: 10.16438/j.0513-4870.2021-1203
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Article Info
doi: 10.16438/j.0513-4870.2021-1203
  • Receive Date：2021-08-19
  • Online Date：2025-12-22
  • Published：2022-04-12
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  • Received：2021-08-19
  • Revised：2021-09-29
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Affiliations
    Department of Breast Cancer Pathology and Research Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin 300060, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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