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Chemical constituents of soft coral Sarcophyton glaucum collected from Xisha and their anti-inflammatory activity
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Jin-feng LI1, 2, 3, Li-gong YAO2, Yan-bo ZENG1, 3, *, Yue-wei GUO2, 4, *
Acta Pharmaceutica Sinica | 2022, 57(3) : 741 - 749
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Acta Pharmaceutica Sinica | 2022, 57(3): 741-749
• Original Articles •
Chemical constituents of soft coral Sarcophyton glaucum collected from Xisha and their anti-inflammatory activity
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Jin-feng LI1, 2, 3, Li-gong YAO2, Yan-bo ZENG1, 3, *, Yue-wei GUO2, 4, *
Affiliations
  • 1. Ocean College of Hebei Agricultural University, Qinhuangdao 066000, China
  • 2. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • 3. Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
  • 4. Bohai rim Advanced Research Institute for Drug Discovery, Yantai 264000, China
Published: 2022-03-12 doi: 10.16438/j.0513-4870.2021-1292
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The crude Et2O extract of soft coral Sarcophyton glaucum, collected off the Xisha, the South China Sea, were investigated. A new cembrane-type diterpenoid, namely 15-dehydroxy-sarcophytrol D (1), together with twenty-five known compounds, namely ximaoglaucumin C (2), (11S, 12S, 1E, 3E, 7E)-11, 12-epoxycembra-1, 3, 7-triene (3), sarcophytol W (4), cembrene (5), sarcophytol B (6), sarcophytol K (7), sarcophytol J (8), pentaene-cembrene (9), sarcophytol E (10), (+)-marasol (11), (2S)-sarcophytoninsarcophytoxide (12), (-)-17-hydroxydeepoxysarcophytoxide (13), (+)-sarcophytoxide (14), 13-acetoxysarcophytoxide (15), bophynin B (16), 16-oxosarcophytoxide E (17), sarcophinone (18), 7α-8β-dihydroxydeepoxysarcophine (19), (+)-sarcophine (20), 14-dehydroxy-sarcophytol L (21), sarcophytol L (22), 13α-hydroxy-sarcophytol L (23), trocheliophol C (24), trocheliophol E (25) and trocheliophol L (26), were isolated and purified by comprehensive chromatography methods of silica gel column, Sephadex LH-20 gel column, TLC, and semi-preparative high-performance liquid chromatography (HPLC). In anti-inflammatory bioassay, compound 4 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced inflammatory responses in BV-2 microglial cells.

soft coral  /  Sarcophyton glaucum  /  diterpenoid  /  15-dehydroxy-sarcophytol D  /  anti-inflammatory activity
Jin-feng LI, Li-gong YAO, Yan-bo ZENG, Yue-wei GUO. Chemical constituents of soft coral Sarcophyton glaucum collected from Xisha and their anti-inflammatory activity[J]. Acta Pharmaceutica Sinica, 2022 , 57 (3) : 741 -749 . DOI: 10.16438/j.0513-4870.2021-1292
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Article Info
doi: 10.16438/j.0513-4870.2021-1292
  • Receive Date：2021-09-06
  • Online Date：2025-12-22
  • Published：2022-03-12
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History
  • Received：2021-09-06
  • Revised：2021-09-30
Funding
Affiliations
    1. Ocean College of Hebei Agricultural University, Qinhuangdao 066000, China
    2. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    3. Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
    4. Bohai rim Advanced Research Institute for Drug Discovery, Yantai 264000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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