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Design and research progress of nano-drug delivery system based on mitochondria targeting
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Bao-xin ZHENG1, Chang-fen BI2, Wen-bin HOU2, *, Yi-liang LI2, *
Acta Pharmaceutica Sinica | 2022, 57(3) : 681 - 694
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Acta Pharmaceutica Sinica | 2022, 57(3): 681-694
• Reviews •
Design and research progress of nano-drug delivery system based on mitochondria targeting
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Bao-xin ZHENG1, Chang-fen BI2, Wen-bin HOU2, *, Yi-liang LI2, *
Affiliations
  • 1. Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
  • 2. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Tianjin 300192, China
Published: 2022-03-12 doi: 10.16438/j.0513-4870.2021-1321
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Mitochondria is involved in many important physiological activities such as energy supply, signal transduction, cell differentiation, etc., and plays an significant role in the occurrence and development of diseases. Using mitochondria as a target is a new strategy for cancer treatment. The use of nanotechnology to construct a mitochondrial targeted nano-drug delivery system can improve the solubility of traditional drugs, prolong the half-life of drugs in the body, increase the bioavailability and concentration of drugs at the tumor site, and reduce the toxic and side effects of drugs. It is expected to solve the resistance in the process of tumor treatment. This review focuses on the field of cancer treatment. Firstly, it introduces the mechanism of mitochondrial targeted nano-drug delivery system for cancer treatment. Secondly, it outlines the design ideas, classification and application research of mitochondrial targeted nano-drug delivery systems in the past five years. Finally, it expands the analysis of other studies that target mitochondria, such as bionic vectors, and presents its advantages and disadvantages, which provide a basis for in-depth research on drug delivery systems in the future.

neoplasm  /  mitochondria  /  targeting  /  drug delivery system  /  chemotherapy  /  nanotechnology  /  therapy
Bao-xin ZHENG, Chang-fen BI, Wen-bin HOU, Yi-liang LI. Design and research progress of nano-drug delivery system based on mitochondria targeting[J]. Acta Pharmaceutica Sinica, 2022 , 57 (3) : 681 -694 . DOI: 10.16438/j.0513-4870.2021-1321
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Article Info
doi: 10.16438/j.0513-4870.2021-1321
  • Receive Date：2021-09-10
  • Online Date：2025-12-22
  • Published：2022-03-12
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History
  • Received：2021-09-10
  • Revised：2021-11-02
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Affiliations
    1. Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
    2. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Tianjin 300192, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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