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Current status and prospects for treatment of diabetic retinopathy
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Wei-wen KONG1, 2, Jin REN1, 2, *
Acta Pharmaceutica Sinica | 2022, 57(2) : 287 - 295
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Acta Pharmaceutica Sinica | 2022, 57(2): 287-295
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Current status and prospects for treatment of diabetic retinopathy
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Wei-wen KONG1, 2, Jin REN1, 2, *
Affiliations
  • 1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • 2. University of Chinese Academy of Sciences, Beijing 100049, China
Published: 2022-02-12 doi: 10.16438/j.0513-4870.2021-0519
Outline
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Diabetic retinopathy (DR), one of the common complications of diabetes, is the main cause of blindness. Due to the limitations of the existing clinical treatment methods, it is urgent to develop new targets or/and new therapeutic drugs. This review summarizes the clinical trials of anti-DR drugs in recent years, and we note that gene therapy is a potential direction for DR treatment development. Due to the characteristics of ocular structure, including small size, a relatively independent organ, immune privilege and the opportunity for local administration, gene therapy could well be advantageous in the treatment of DR. Furthermore, the long-term therapeutic effects of gene therapy also improve compliance by DR patients. All these indicate that gene therapy is likely a future direction for development of DR therapies.

diabetic retinopathy  /  pathological mechanism  /  treatment limitation  /  clinical trial  /  gene therapy
Wei-wen KONG, Jin REN. Current status and prospects for treatment of diabetic retinopathy[J]. Acta Pharmaceutica Sinica, 2022 , 57 (2) : 287 -295 . DOI: 10.16438/j.0513-4870.2021-0519
Year 2022 volume 57 Issue 2
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Article Info
doi: 10.16438/j.0513-4870.2021-0519
  • Receive Date:2021-04-08
  • Online Date:2025-12-22
  • Published:2022-02-12
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  • Received:2021-04-08
  • Revised:2021-06-21
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    1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    2. University of Chinese Academy of Sciences, Beijing 100049, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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