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Effect of fudosteine on lung cancer cells in an inflammatory microenvironment based on metabolomics
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Yi-fei WANG1, Qi-le ZHANG1, Xin LI1, Meng-ting GAO1, Li ZHANG1, An-wei DING1, Wen-yu XIA2, Wei-feng YAO*, 1
Acta Pharmaceutica Sinica | 2022, 57(2) : 419 - 427
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Acta Pharmaceutica Sinica | 2022, 57(2): 419-427
• Original Articles •
Effect of fudosteine on lung cancer cells in an inflammatory microenvironment based on metabolomics
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Yi-fei WANG1, Qi-le ZHANG1, Xin LI1, Meng-ting GAO1, Li ZHANG1, An-wei DING1, Wen-yu XIA2, Wei-feng YAO*, 1
Affiliations
  • 1. Jiangsu Key Laboratory for High Technology Research of TCM Formulae and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
  • 2. Jiangsu Chia Tai Fenghai Pharmaceutical Co., Ltd., Yancheng 224100, China
Published: 2022-02-12 doi: 10.16438/j.0513-4870.2021-1094
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GC-MS metabolomics was used to investigate the effects of fudosteine on lung cancer A549 cells in an inflammatory microenvironment. Eleven metabolites (malic acid, isoleucine, lactose, galactinol, creatinine, gluconic acid, oleic acid, phosphate, S-carboxymethyl-L-cysteine, uridine and tagatose) were identified in the metabolomics results and could be used as biomarkers of fudosteine treatment. Pathway enrichment analysis showed that the metabolic pathways of amino acids including isoleucine, valine, leucine, glycine, serine and threonine were significantly altered, as were the metabolic pathways of carbohydrates such as galactose and pentose phosphate. Fudosteine significantly reduced the level of inflammatory factors in A549 cells and corrected the inflammatory microenvironment by interfering with the effects of amino acid metabolites and amino acid metabolism pathways. This study reveals that fudosteine may be able to inhibit the continuous inflammatory response and prevent the further progression of lung cancer by suppressing the inflammatory microenvironment.

fudosteine  /  inflammatory microenvironment  /  A549  /  metabolomics  /  GC-MS
Yi-fei WANG, Qi-le ZHANG, Xin LI, Meng-ting GAO, Li ZHANG, An-wei DING, Wen-yu XIA, Wei-feng YAO. Effect of fudosteine on lung cancer cells in an inflammatory microenvironment based on metabolomics[J]. Acta Pharmaceutica Sinica, 2022 , 57 (2) : 419 -427 . DOI: 10.16438/j.0513-4870.2021-1094
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doi: 10.16438/j.0513-4870.2021-1094
  • Receive Date：2021-07-23
  • Online Date：2025-12-22
  • Published：2022-02-12
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  • Received：2021-07-23
  • Revised：2021-10-20
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Affiliations
    1. Jiangsu Key Laboratory for High Technology Research of TCM Formulae and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
    2. Jiangsu Chia Tai Fenghai Pharmaceutical Co., Ltd., Yancheng 224100, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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