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The applications of ionic liquids in drug delivery
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Yu-xin JIANG1, Qi JIANG1, Di WANG1, Wan-ting ZHANG1, Wei HE1, *, Ming YANG2, *
Acta Pharmaceutica Sinica | 2022, 57(2) : 331 - 342
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Acta Pharmaceutica Sinica | 2022, 57(2): 331-342
• Reviews •
The applications of ionic liquids in drug delivery
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Yu-xin JIANG1, Qi JIANG1, Di WANG1, Wan-ting ZHANG1, Wei HE1, *, Ming YANG2, *
Affiliations
  • 1. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
  • 2. Key Laboratory of Modern Chinese Medicine Preparations of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Published: 2022-02-12 doi: 10.16438/j.0513-4870.2021-0791
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Ionic liquids (ILs) are liquid mixtures formed by anions and cations in a certain stoichiometric ratio under certain conditions. They are widely used in various fields because of their simple preparation process, low volatility, high stability, high conductivity and non-flammability. Here, we firstly introduce their formation principles, classification, and physical and chemical properties in detail. Then, we summarize their functions in pharmaceutical preparations, such as improving the solubility of insoluble drugs, enhancing the stability of drugs, and promoting the permeability of drugs, as well as their role as active pharmaceutical ingredients (API) to fabricate new drug delivery systems of API-ILs. Finally, we reviewed the applications of ILs in different administration routes, including oral, transdermal, mucosal, and injection routes, and meanwhile offer perspectives for the further use of ILs.

ionic liquid  /  drug delivery system  /  solubility  /  oral administration  /  cutaneous administration
Yu-xin JIANG, Qi JIANG, Di WANG, Wan-ting ZHANG, Wei HE, Ming YANG. The applications of ionic liquids in drug delivery[J]. Acta Pharmaceutica Sinica, 2022 , 57 (2) : 331 -342 . DOI: 10.16438/j.0513-4870.2021-0791
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Article Info
doi: 10.16438/j.0513-4870.2021-0791
  • Receive Date：2021-05-26
  • Online Date：2025-12-22
  • Published：2022-02-12
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History
  • Received：2021-05-26
  • Revised：2021-07-21
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Affiliations
    1. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
    2. Key Laboratory of Modern Chinese Medicine Preparations of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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