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Preparation of oxytocin liposomes modified by cell penetrating peptides and evaluation on brain targeting efficiency via intranasal delivery
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Feng-mei LÜ, Hui-min LIANG, Li SUI, Zhe-peng LIU*
Acta Pharmaceutica Sinica | 2022, 57(2) : 500 - 506
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Acta Pharmaceutica Sinica | 2022, 57(2): 500-506
• Original Articles •
Preparation of oxytocin liposomes modified by cell penetrating peptides and evaluation on brain targeting efficiency via intranasal delivery
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Feng-mei LÜ, Hui-min LIANG, Li SUI, Zhe-peng LIU*
Affiliations
  • University of Shanghai for Science and Technology, Shanghai 200093, China
Published: 2022-02-12 doi: 10.16438/j.0513-4870.2021-0856
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The water-soluble polypeptide drug oxytocin was encapsulated in liposomes by reverse-phase evaporation vesicle method to obtain oxytocin loaded liposomes (OT@LPs) which was further modified with cationic cell penetrating peptide-arginine octamer (R8) to get R8 modified oxytocin loaded liposomes (OT@LPs-R8) which showed enhanced mucoadhesive. The brain targeting efficiency was evaluated preliminarily after nasal administration. OT@LPs-R8 showed a round shape with a particle size distribution of 110.2±7.3 nm, a surface potential as high as +18 mV, a drug loading (62.17±1.88)%, an encapsulation rate (5.85±0.72)%, and stood stable in nasal mucus. After nasal administration, it could significantly prolong the retention and enhance the distribution in the brain with no irritation to the nasal mucosa. The animal experiment in line with the regulations of the Department of Laboratory Animal Science of Fudan University on the ethics of animal experiments had been carried out after passing the review of the Animal Ethics Committee of Fudan University. The results showed nasal administration of OT@LPs-R8 could promote oxytocin directly into the brain from the nose which expected to become a new carrier for delivery of oxytocin to the brain.

oxytocin  /  cell-penetrating peptide  /  arginine octamer  /  liposome  /  mucoadhesive  /  nose-to-brain delivery
Feng-mei LÜ, Hui-min LIANG, Li SUI, Zhe-peng LIU. Preparation of oxytocin liposomes modified by cell penetrating peptides and evaluation on brain targeting efficiency via intranasal delivery[J]. Acta Pharmaceutica Sinica, 2022 , 57 (2) : 500 -506 . DOI: 10.16438/j.0513-4870.2021-0856
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Year 2022 volume 57 Issue 2
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doi: 10.16438/j.0513-4870.2021-0856
  • Receive Date：2021-06-10
  • Online Date：2025-12-22
  • Published：2022-02-12
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  • Received：2021-06-10
  • Revised：2021-07-17
Affiliations
    University of Shanghai for Science and Technology, Shanghai 200093, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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