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Review of the in vitro inhibitory effects of traditional Chinese medicine and its components on CYP450 enzymes in liver microsomes
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Wen-wen ZHANG1, Xin LIU2, Cheng-ming WEN1, Xue-hua JIANG1, Ling WANG1, *
Acta Pharmaceutica Sinica | 2022, 57(2) : 303 - 312
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Acta Pharmaceutica Sinica | 2022, 57(2): 303-312
• Reviews •
Review of the in vitro inhibitory effects of traditional Chinese medicine and its components on CYP450 enzymes in liver microsomes
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Wen-wen ZHANG1, Xin LIU2, Cheng-ming WEN1, Xue-hua JIANG1, Ling WANG1, *
Affiliations
  • 1. Department of Clinical Pharmacy and Pharmacy Administration, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
  • 2. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410000, China
Published: 2022-02-12 doi: 10.16438/j.0513-4870.2021-1384
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Cytochrome P450s (CYP450) is a superfamily of phase I metabolic enzymes, which participates in more than 90% of drug oxidation. The induction or inhibition of CYP450s is the main mechanism of drug-drug interaction. In recent years, in vitro metabolism studies conducted through isolated organs, cells, or enzyme systems have developed rapidly, due to their precision and simplicity. Therefore, profiles of the in vitro metabolism studies of traditional Chinese medicines can infer the possible metabolic pathways of drugs, predict the potential drug interactions, and may enhance the rational use of drugs in clinic. This article reviews the in vitro inhibitory effects of traditional Chinese medicine, ingredients, and extracts on the activities of CYP450 enzymes in the liver microsomes, which can provide a reference for further researches on the interaction between Chinese medicine and chemical medicine.

cytochrome P450  /  traditional Chinese medicine  /  in vitro metabolism  /  liver microsome  /  drug-drug interaction
Wen-wen ZHANG, Xin LIU, Cheng-ming WEN, Xue-hua JIANG, Ling WANG. Review of the in vitro inhibitory effects of traditional Chinese medicine and its components on CYP450 enzymes in liver microsomes[J]. Acta Pharmaceutica Sinica, 2022 , 57 (2) : 303 -312 . DOI: 10.16438/j.0513-4870.2021-1384
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Article Info
doi: 10.16438/j.0513-4870.2021-1384
  • Receive Date：2021-09-18
  • Online Date：2025-12-22
  • Published：2022-02-12
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History
  • Received：2021-09-18
  • Revised：2021-11-03
Affiliations
    1. Department of Clinical Pharmacy and Pharmacy Administration, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
    2. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410000, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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