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Research progress in nano-drug delivery systems for antitumor multi-drug combinational application
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Wen-xin JIANG1, Hua-qing ZHANG1, 2, Yang DING1, 3, *, Jian-ping ZHOU1, 2, 3, *
Acta Pharmaceutica Sinica | 2022, 57(1) : 1 - 12
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Acta Pharmaceutica Sinica | 2022, 57(1): 1-12
• Reviews •
Research progress in nano-drug delivery systems for antitumor multi-drug combinational application
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Wen-xin JIANG1, Hua-qing ZHANG1, 2, Yang DING1, 3, *, Jian-ping ZHOU1, 2, 3, *
Affiliations
  • 1. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
  • 2. Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China
  • 3. NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Nanjing 210009, China
Published: 2022-01-12 doi: 10.16438/j.0513-4870.2021-0787
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Due to the complexity of tumor pathology, the demand for the combined use of multiple drugs in clinical treatment has become increasingly clear-cut. Multi-drug combination can act on multiple pathways and multiple targets simultaneously to exert synergistic effects. However, the current delivery strategy for multi-drug combination still needs to be optimized. Nano-drug delivery systems can carry drugs to overcome physiological and pathological barrier to target tumor tissues and cells, achieve the goal of continuous, controllable, and targeted delivery, and enhance the efficacy of anti-tumor synergism and detoxification. To meet the new requirements for smarter and more accurate antitumor multi-drug combinational therapy, the nano-drug delivery system has been well-designed to realize more functions. For instance, delivery of multiple drugs in accurate proportions and doses can make the multi-drug synergistic effect more precise; stimulus-responsive drug release can improve selectivity and reduce side effects; controlling the time-course relationship of multiple drugs can realize sequential drug combination effect. It has shown broad prospects in the field of tumor multidrug therapy and has become one of the new directions of research and development. This article reviews the recent developments in the application of tumor drug combination therapy strategies and their delivery systems, and analyzes the new requirements and challenges of multidrug combination for the development of nano-drug delivery systems.

antitumor  /  drug combination  /  nanomedicine  /  drug delivery system  /  multimodal treatment
Wen-xin JIANG, Hua-qing ZHANG, Yang DING, Jian-ping ZHOU. Research progress in nano-drug delivery systems for antitumor multi-drug combinational application[J]. Acta Pharmaceutica Sinica, 2022 , 57 (1) : 1 -12 . DOI: 10.16438/j.0513-4870.2021-0787
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Article Info
doi: 10.16438/j.0513-4870.2021-0787
  • Receive Date：2021-05-25
  • Online Date：2025-12-22
  • Published：2022-01-12
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History
  • Received：2021-05-25
  • Revised：2021-06-16
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Affiliations
    1. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
    2. Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China
    3. NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, Nanjing 210009, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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