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Advances of microneedle vaccines in transcutaneous immunization
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Yang-yan CHEN1, Yao HUANG1, Wan-shan HU2, Min-qun DU3, Ting-ting PENG2, *, Xin PAN1, Chuan-bin WU2, *
Acta Pharmaceutica Sinica | 2022, 57(1) : 142 - 149
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Acta Pharmaceutica Sinica | 2022, 57(1): 142-149
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Advances of microneedle vaccines in transcutaneous immunization
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Yang-yan CHEN1, Yao HUANG1, Wan-shan HU2, Min-qun DU3, Ting-ting PENG2, *, Xin PAN1, Chuan-bin WU2, *
Affiliations
  • 1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
  • 2. College of Pharmacy, Jinan University, Guangzhou 510632, China
  • 3. Guangdong Women and Children Hospital, Guangzhou 511442, China
Published: 2022-01-12 doi: 10.16438/j.0513-4870.2021-1297
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Vaccination is an effective way to reduce the morbidity and mortality of infectious diseases. As a needle-free transcutaneous immunization (NF-TCI) vaccination technology, microneedles (MNs), composed of multiple micro-needles orderly attached to a substrate, can overcome the problems of low immune efficiency, poor compliance and waste of resources that exists in the conventional vaccination by injection, thus becoming a research hotspot in biomedicine. The microneedle vaccine can directly break through the stratum corneum barrier of the skin without touching nerves and blood vessels in the dermis, and effectively delivers the vaccine to the immune cells in the skin tissue to initiate the immune response of the body, thus triggering strong humoral and cellular immune processes. Vaccine delivery via the MNs system possesses the advantages of high safety, satisfying immune effect and practical economy, and shows great prospect in the prevention and treatment of infectious diseases and antineoplastic therapy. This article reviews the development background of MNs in transcutaneous immunization, the types of vaccine delivery, the factors affecting the immune effect, the problems to be solved and development direction in the future.

transcutaneous immunization  /  microneedle  /  vaccine  /  infectious disease  /  tumor
Yang-yan CHEN, Yao HUANG, Wan-shan HU, Min-qun DU, Ting-ting PENG, Xin PAN, Chuan-bin WU. Advances of microneedle vaccines in transcutaneous immunization[J]. Acta Pharmaceutica Sinica, 2022 , 57 (1) : 142 -149 . DOI: 10.16438/j.0513-4870.2021-1297
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doi: 10.16438/j.0513-4870.2021-1297
  • Receive Date：2021-09-13
  • Online Date：2025-12-22
  • Published：2022-01-12
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  • Received：2021-09-13
  • Revised：2021-09-28
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Affiliations
    1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
    2. College of Pharmacy, Jinan University, Guangzhou 510632, China
    3. Guangdong Women and Children Hospital, Guangzhou 511442, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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