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Progress on active tumor-targeting nano drug delivery systems for improving tumor immunotherapy
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Wen-lu YAN1, 2, Tian-qun LANG1, Qi YIN1, *, Ya-ping LI1, 2, *
Acta Pharmaceutica Sinica | 2022, 57(1) : 46 - 63
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Acta Pharmaceutica Sinica | 2022, 57(1): 46-63
• Reviews •
Progress on active tumor-targeting nano drug delivery systems for improving tumor immunotherapy
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Wen-lu YAN1, 2, Tian-qun LANG1, Qi YIN1, *, Ya-ping LI1, 2, *
Affiliations
  • 1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • 2. School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China
Published: 2022-01-12 doi: 10.16438/j.0513-4870.2021-1172
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In recent years, immunotherapy has made great progress in clinical cancer therapy. However, the poor tumor specificity, low intra-tumoral penetration, and low cellular uptake in the systemic delivery of immunotherapeutic drugs lead to low efficacy and poor safety, limiting the development of immunotherapy. Active tumor-targeting nano drug delivery systems (aNDDS) can enhance the concentration of drugs in target cells through the interaction between surface-conjugated antibodies or ligands and the receptors on target cell membranes, providing a viable strategy for specific and efficient drug delivery. In addition, some specific types of cell membranes with the natural targeting ability have been exploited for the construction of biomimetic nanocarriers to improve the drug delivery efficiency. In view of the many advantages of active tumor-targeting nanocarriers, researchers also have designed a series of aNDDS for promoting antitumor immune responses and proved that they improved the efficacy and safety of immunotherapy. In this review, we summarize the recent progress on aNDDS for improving the tumor immunotherapy and look forward to the main challenges and future directions in this field.

neoplasm  /  immunotherapy  /  drug delivery system  /  nanomedicine  /  biomimetic material  /  immune response  /  tumor microenvironment
Wen-lu YAN, Tian-qun LANG, Qi YIN, Ya-ping LI. Progress on active tumor-targeting nano drug delivery systems for improving tumor immunotherapy[J]. Acta Pharmaceutica Sinica, 2022 , 57 (1) : 46 -63 . DOI: 10.16438/j.0513-4870.2021-1172
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Article Info
doi: 10.16438/j.0513-4870.2021-1172
  • Receive Date：2021-08-11
  • Online Date：2025-12-22
  • Published：2022-01-12
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  • Received：2021-08-11
  • Revised：2021-09-03
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Affiliations
    1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    2. School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
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小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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