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Phospholipid peroxidation: a key factor in "susceptibility" to neurodegenerative diseases
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Xiao-min LIN1, 2, Wan-yang SUN1, 2, Wen-jun DUAN1, 2, 3, Hai-biao GONG1, 2, Long-fang TU1, 2, Yi-fang LI1, 2, Hiroshi KURIHARA1, 2, Rong-rong HE1, 2, 3, *
Acta Pharmaceutica Sinica | 2021, 56(8) : 2154 - 2163
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Acta Pharmaceutica Sinica | 2021, 56(8): 2154-2163
• Reviews •
Phospholipid peroxidation: a key factor in "susceptibility" to neurodegenerative diseases
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Xiao-min LIN1, 2, Wan-yang SUN1, 2, Wen-jun DUAN1, 2, 3, Hai-biao GONG1, 2, Long-fang TU1, 2, Yi-fang LI1, 2, Hiroshi KURIHARA1, 2, Rong-rong HE1, 2, 3, *
Affiliations
  • 1. Guangdong Engineering Research Center of Chinese Medicine and Disease Susceptibility, Jinan University, Guangzhou 510632, China
  • 2. College of Pharmacy, Jinan University, Guangzhou 510632, China
  • 3. School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China
Published: 2021-08-12 doi: 10.16438/j.0513-4870.2021-0188
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The biochemical integrity of the brain is necessary to maintain normal function. Oxidative damage is one of the mortal important reasons leading to the destruction of this integrity. The nervous system is enriched in phospholipid and polyunsaturated fatty acids (PUFAs). Due to the nature of high oxygen-consumption and rich lipids, brain is particularly vulnerable to oxidative damages. Phospholipid peroxidation is one of the results of imbalance in oxidation-antioxidant system. Once the antioxidant system is insufficient to resist oxidative damage, membrane phospholipids will be prone to free radical attack. Phospholipid peroxidation leads to a variety of toxic oxidation products, including membrane damage, mitochondrial dysfunction, rapid accumulation of amyloid, etc. Multiple proteins and nucleic acids can be covalently modified by peroxidation products, resulting in the loss of the protein functions, which eventually triggers programmed cell death and general neuroinflammation in brain, and ends up with an increased susceptibility to neurodegenerative diseases. Based on the knowledge of mechanisms of phospholipid peroxidation, this review focuses on the characteristics of phospholipid peroxidation as a key factor in the development of neurodegenerative diseases, in order to provide theoretical basis for targeted intervention of phospholipid peroxidation as a potential strategy to prevent neurodegenerative diseases.

phospholipid peroxidation  /  neurodegenerative disease  /  disease susceptibility  /  ferroptosis  /  oxidative stress
Xiao-min LIN, Wan-yang SUN, Wen-jun DUAN, Hai-biao GONG, Long-fang TU, Yi-fang LI, Hiroshi KURIHARA, Rong-rong HE. Phospholipid peroxidation: a key factor in "susceptibility" to neurodegenerative diseases[J]. Acta Pharmaceutica Sinica, 2021 , 56 (8) : 2154 -2163 . DOI: 10.16438/j.0513-4870.2021-0188
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Article Info
doi: 10.16438/j.0513-4870.2021-0188
  • Receive Date：2021-02-02
  • Online Date：2025-12-18
  • Published：2021-08-12
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History
  • Received：2021-02-02
  • Revised：2021-03-10
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Affiliations
    1. Guangdong Engineering Research Center of Chinese Medicine and Disease Susceptibility, Jinan University, Guangzhou 510632, China
    2. College of Pharmacy, Jinan University, Guangzhou 510632, China
    3. School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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