收藏切换
Research advances on the effect of ginsenoside Rg1 on angiogenesis and vascular protection
收藏切换
PDF
Yan-tao YANG1, 2, 3, Yan YANG1, 2, 3, Jia-mei XIAO1, 2, Nai-hong CHEN1, 3, 4, *
Acta Pharmaceutica Sinica | 2021, 56(8) : 2146 - 2153
Less
收藏切换
Acta Pharmaceutica Sinica | 2021, 56(8): 2146-2153
Reviews
Research advances on the effect of ginsenoside Rg1 on angiogenesis and vascular protection
Full
Yan-tao YANG1, 2, 3, Yan YANG1, 2, 3, Jia-mei XIAO1, 2, Nai-hong CHEN1, 3, 4, *
Affiliations
  • 1. Pharmacy School, Hunan University of Chinese Medicine, Changsha 410208, China
  • 2. Druggability and Preparation of Chinese Medicine Key Laboratory of Hunan Province, Changsha 410208, China
  • 3. Center for Standardization and Functional Engineering of Traditional Chinese Medicine in Hunan Province, Changsha 410208, China
  • 4. Neuroscience Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2021-08-12 doi: 10.16438/j.0513-4870.2021-0107
Outline
收藏切换

Ginsenoside Rg1 is one of the most important active components of the "king of herbs" Panax ginseng, which is an important angiogenic protective agent. The research results have shown that Rg1 has a wide range of cardiovascular pharmacological effects in vivo and in vitro, mainly through promoting the proliferation of smooth muscle cells, inhibiting endothelial cell aging, antioxidant stress, inhibiting inflammatory response, activating key factors of angiogenesis, improving vasodilation and other ways. Many miRNAs participate in the process of Rg1 promoting angiogenesis, mediate the regulation of the specific expression of downstream related targets to promote angiogenesis and vascular remodeling, and have the potential to become new clinical biomarkers and therapeutic targets. New preparation technologies and materials are used to make up for the weakness of Rg1's blood-brain barrier permeability, and further promote and enrich the clinical application of Rg1.

ginsenoside Rg1  /  miRNA  /  endothelial cell  /  preparation material  /  angiogenesis
Yan-tao YANG, Yan YANG, Jia-mei XIAO, Nai-hong CHEN. Research advances on the effect of ginsenoside Rg1 on angiogenesis and vascular protection[J]. Acta Pharmaceutica Sinica, 2021 , 56 (8) : 2146 -2153 . DOI: 10.16438/j.0513-4870.2021-0107
Year 2021 volume 56 Issue 8
PDF
181
69
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2021-0107
  • Receive Date:2021-01-19
  • Online Date:2025-12-18
  • Published:2021-08-12
Article Data
Affiliations
History
  • Received:2021-01-19
  • Revised:2021-02-27
Funding
Affiliations
    1. Pharmacy School, Hunan University of Chinese Medicine, Changsha 410208, China
    2. Druggability and Preparation of Chinese Medicine Key Laboratory of Hunan Province, Changsha 410208, China
    3. Center for Standardization and Functional Engineering of Traditional Chinese Medicine in Hunan Province, Changsha 410208, China
    4. Neuroscience Center, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2021-0107
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT