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Improving compactibility properties of Lonicera Japonica Flos by Plasdone S-630
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Wen ZHANG1, Ya-ting YU1, Li-jie ZHAO1, *, Jun-hong ZHANG2, You-jie WANG1, Lan SHEN3, Ruo-fei DU1, Yan-long HONG4, Yi FENG1, *
Acta Pharmaceutica Sinica | 2021, 56(8) : 2127 - 2135
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Acta Pharmaceutica Sinica | 2021, 56(8): 2127-2135
• Special Reports: Structural Chinese Medicine •
Improving compactibility properties of Lonicera Japonica Flos by Plasdone S-630
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Wen ZHANG1, Ya-ting YU1, Li-jie ZHAO1, *, Jun-hong ZHANG2, You-jie WANG1, Lan SHEN3, Ruo-fei DU1, Yan-long HONG4, Yi FENG1, *
Affiliations
  • 1. Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 2. Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development, Zhangzhou 363000, China
  • 3. College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 4. Health Service Collaborative Innovation Center of Shanghai Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Published: 2021-08-12 doi: 10.16438/j.0513-4870.2021-0514
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To improve the fluidity and compactibility properties of raw powders of traditional Chinese medicine by particle modification technology, Lonicera Japonica Flos was used as a model drug, fluidized bed bottom spray technology was used, and Plasdone S-630 was used as a modifier to prepare modified particles. The powder properties, tablet compactibility parameters, disintegration time and dissolution were measured. The surface morphology of the powder particles before and after modification and compressed tablets were characterized by combining with scanning electron microscopy technology. The results showed that the particle size of Lonicera Japonica powder has been increased after particle modification, the fluidity, compressibility and compactibility of the powder have been improved to some extent, the disintegration time has also been reduced, and the dissolution in vitro is not affected. Therefore, this study can provide reference and ideas for the common problem that raw powder of traditional Chinese medicine that cannot meet the needs of preparation production due to poor powder properties such as fluidity and compressibility.

Lonicera Japonica  /  particle modification  /  fluidity  /  compactibility  /  fluid-bed technology
Wen ZHANG, Ya-ting YU, Li-jie ZHAO, Jun-hong ZHANG, You-jie WANG, Lan SHEN, Ruo-fei DU, Yan-long HONG, Yi FENG. Improving compactibility properties of Lonicera Japonica Flos by Plasdone S-630[J]. Acta Pharmaceutica Sinica, 2021 , 56 (8) : 2127 -2135 . DOI: 10.16438/j.0513-4870.2021-0514
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Article Info
doi: 10.16438/j.0513-4870.2021-0514
  • Receive Date：2021-04-08
  • Online Date：2025-12-18
  • Published：2021-08-12
Article Data
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History
  • Received：2021-04-08
  • Revised：2021-05-09
Funding
Affiliations
    1. Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2. Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development, Zhangzhou 363000, China
    3. College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    4. Health Service Collaborative Innovation Center of Shanghai Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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