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Research progress and thinking on improving physicochemical properties and efficacy of the active ingredients in traditional Chinese medicine based on crystal structure
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Ying-chong CHEN, Wei-cheng ZHOU, fang-fang LEI, Li-zhen HUANG, Qin ZHENG, Ming YANG, Peng-fei YUE*
Acta Pharmaceutica Sinica | 2021, 56(8) : 2059 - 2069
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Acta Pharmaceutica Sinica | 2021, 56(8): 2059-2069
• Special Reports: Structural Chinese Medicine •
Research progress and thinking on improving physicochemical properties and efficacy of the active ingredients in traditional Chinese medicine based on crystal structure
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Ying-chong CHEN, Wei-cheng ZHOU, fang-fang LEI, Li-zhen HUANG, Qin ZHENG, Ming YANG, Peng-fei YUE*
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  • Key Lab of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Published: 2021-08-12 doi: 10.16438/j.0513-4870.2021-0813
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The active ingredients in traditional Chinese medicine have been reported to possess significant pharmacological activity and played an important role in clinical treatments. However, lots of the active ingredients in traditional Chinese medicine suffer from disadvantages such as low solubility, high melting point and low stability that results in low bioavailability and limit its clinical application. Crystal structure plays an important role in improving physicochemical properties and efficacy of the active ingredients in traditional Chinese medicine. This review concludes the research advances of several crystal forms used in the active ingredients in traditional Chinese medicine in terms of polymorph, cocrystal, amorphous/coamorphous and nanocrystal. And the effects of crystal forms on the physicochemical properties and efficacy of the active ingredients in traditional Chinese medicine were reviewed. This research may be useful for the formulation preparation and development of the active ingredients in traditional Chinese medicine.

traditional Chinese medicine  /  active ingredient  /  crystal structure  /  physicochemical property  /  efficacy
Ying-chong CHEN, Wei-cheng ZHOU, fang-fang LEI, Li-zhen HUANG, Qin ZHENG, Ming YANG, Peng-fei YUE. Research progress and thinking on improving physicochemical properties and efficacy of the active ingredients in traditional Chinese medicine based on crystal structure[J]. Acta Pharmaceutica Sinica, 2021 , 56 (8) : 2059 -2069 . DOI: 10.16438/j.0513-4870.2021-0813
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Year 2021 volume 56 Issue 8
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doi: 10.16438/j.0513-4870.2021-0813
  • Receive Date：2021-06-01
  • Online Date：2025-12-18
  • Published：2021-08-12
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  • Received：2021-06-01
  • Revised：2021-06-29
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    Key Lab of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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