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Research progress on preparation technology of nanocrystal drugs
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Yang TIAN, Yi-fan PENG, Zhi-wei ZHANG, Hui ZHANG*, Xiang GAO*
Acta Pharmaceutica Sinica | 2021, 56(7) : 1902 - 1910
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Acta Pharmaceutica Sinica | 2021, 56(7): 1902-1910
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Research progress on preparation technology of nanocrystal drugs
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Yang TIAN, Yi-fan PENG, Zhi-wei ZHANG, Hui ZHANG*, Xiang GAO*
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  • China Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850
Published: 2021-07-12 doi: 10.16438/j.0513-4870.2021-0248
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Nanocrystal drugs have many advantages, such as no carrier materials, easy industrialization, diversified dosage forms, and can significantly improve the solubility and bioavailability of insoluble drugs, so many drugs have been on the market. The traditional nanocrystal preparation technology has the problems of low preparation efficiency and process limitation of the smallest achievable particle size. With the progress of pharmaceutical preparation technology, the preparation technology of nanocrystal drugs is constantly improving, and new preparation technologies are constantly emerging. The emergence of new technologies has greatly shortened the process time and makes it possible to prepare nanocrystal drugs with smaller particle diameters. In this paper, the preparation technologies of nanocrystal drugs, especially the new preparation technologies such as high gravity controlled precipitation, microfluidic reaction technology and various combination technologies, are reviewed from three aspects: "Top-down" technology, "Bottom-up" technology and combination technology. This article also prospects the development of new preparation technologies, hoping to provide reference for the related research of nano-preparations.

nanocrystal  /  insoluble drug  /  preparation technology  /  solubility  /  bioavailability
Yang TIAN, Yi-fan PENG, Zhi-wei ZHANG, Hui ZHANG, Xiang GAO. Research progress on preparation technology of nanocrystal drugs[J]. Acta Pharmaceutica Sinica, 2021 , 56 (7) : 1902 -1910 . DOI: 10.16438/j.0513-4870.2021-0248
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doi: 10.16438/j.0513-4870.2021-0248
  • Receive Date：2021-02-22
  • Online Date：2025-12-18
  • Published：2021-07-12
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  • Received：2021-02-22
  • Revised：2021-03-29
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    China Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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