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Research progress of effective components of traditional Chinese medicine in anti-aging and anti-tumor mechanism
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Ruo-yu ZHOU1, 2, Man-ting SUN2, Jing LIU2, *, Ying LUO1, 2, *
Acta Pharmaceutica Sinica | 2021, 56(7) : 1856 - 1864
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Acta Pharmaceutica Sinica | 2021, 56(7): 1856-1864
• Reviews •
Research progress of effective components of traditional Chinese medicine in anti-aging and anti-tumor mechanism
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Ruo-yu ZHOU1, 2, Man-ting SUN2, Jing LIU2, *, Ying LUO1, 2, *
Affiliations
  • 1. Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China
  • 2. Laboratory of Molecular Genetics of Aging and Tumor, Medical School, Kunming University of Science and Technology, Kunming 650500, China
Published: 2021-07-12 doi: 10.16438/j.0513-4870.2021-0035
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Increasing research have found a high correlation between senescence and tumor. Cellular senescence can inhibit tumorigenesis while the cellular microenvironment altered by senescent cells can promote the proliferation and metastasis of tumor cells. Some cellular signaling pathways are commonly involved in aging process and carcinogenesis. The deregulation and imbalance of these pathways results into senescence and tumor development. Thus, agents that balance these pathways may effective for anti-aging and anti-tumor. Traditional Chinese medicine (TCM) has been used for the activation of multiple signaling pathways and molecular targets both associated with aging and tumor, with few side effects. Therefore, the article reviewed the cellular signalings that cross between the aging and tumors, and on this basis, summarized the current effective components of TCM with anti-aging and anti-cancer properties, as well as the potential mechanisms of these components in the cross signalings, to provide new research strategies and perspectives for effective components of TCM to treat aging and tumors.

traditional Chinese medicine  /  effective component  /  anti-aging effect  /  anti-tumor activity  /  cellular signaling pathway
Ruo-yu ZHOU, Man-ting SUN, Jing LIU, Ying LUO. Research progress of effective components of traditional Chinese medicine in anti-aging and anti-tumor mechanism[J]. Acta Pharmaceutica Sinica, 2021 , 56 (7) : 1856 -1864 . DOI: 10.16438/j.0513-4870.2021-0035
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Article Info
doi: 10.16438/j.0513-4870.2021-0035
  • Receive Date：2021-01-07
  • Online Date：2025-12-18
  • Published：2021-07-12
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History
  • Received：2021-01-07
  • Revised：2021-03-05
Funding
Affiliations
    1. Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China
    2. Laboratory of Molecular Genetics of Aging and Tumor, Medical School, Kunming University of Science and Technology, Kunming 650500, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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