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Effect of Chuanxiong Rhizoma on the absorption and clearance of four coumarins in Angelicae Dahuricae Radix
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Li-rong LIU1, 2, Zhi-xin JIA2, 3, *, Xiao-ning YAN1, 2, Mei-xia ZHU1, 2, Cong FANG1, 2, Meng-han FENG1, 2, Bei-bei HUANG1, 2, Jie LIU2, 3, Qian LI1, 2, Hong-bin XIAO1, 2, 3, *
Acta Pharmaceutica Sinica | 2021, 56(7) : 1804 - 1810
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Acta Pharmaceutica Sinica | 2021, 56(7): 1804-1810
• Special Reports: Focalizing on the research of the quality control and in vivo process of natural drugs •
Effect of Chuanxiong Rhizoma on the absorption and clearance of four coumarins in Angelicae Dahuricae Radix
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Li-rong LIU1, 2, Zhi-xin JIA2, 3, *, Xiao-ning YAN1, 2, Mei-xia ZHU1, 2, Cong FANG1, 2, Meng-han FENG1, 2, Bei-bei HUANG1, 2, Jie LIU2, 3, Qian LI1, 2, Hong-bin XIAO1, 2, 3, *
Affiliations
  • 1. School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 100029, China
  • 2. Research Center for Chinese Medicine Analysis and Transformation, Beijing University of Chinese Medicine, Beijing 100029, China
  • 3. Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Published: 2021-07-12 doi: 10.16438/j.0513-4870.2021-0592
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To study the changes in the pharmacokinetic behavior of four coumarins (bergapten, oxypeucedanin, imperatorin and isoimperatorin) in rats before and after combinating Angelicae Dahuricae Radix with Chuanxiong Rhizoma. The plasma concentrations of the drugs were determined by ultra performance liquid chromatography-fluorescence detection (UPLC-FLD) for dose response and time dependent curves. The pharmacokinetic parameters were calculated by DAS 3.2.8, and SPSS 20.0 was used to analyze the differences of main pharmacokinetic parameters between the two groups. The result showed: comparing with Angelicae Dahuricae Radix group, the area under drug time curve (AUC0-24 h) of bergapten, oxypeucedanin and imperatorin increased by 177.2%, 97.14% and 54.43% respectively, AUC0-∞ increased by 282.3%, 104.2%, and 75.40% respectively, and clearance rate (CLZ/F) decreased by 68.26%, 51.08% and 43.98% respectively; the peak drug concentration (Cmax) of four coumarins was significantly increased; the distribution volume (VZ/F) of bergapten was significantly decreased. These data indicated that Chuanxiong Rhizoma can promote the absorption of coumarins in Angelicae Dahuricae Radix, slow down the elimination of coumarins, and increase their bioavailability in vivo. The animal experiment scheme in this study has been approved by the Experimental Animal Ethics Committee of Beijing University of Chinese Medicine (approval number: BUCM-4-2020083105-3072).

Angelicae Dahuricae Radix  /  Chuanxiong Rhizoma  /  coumarin  /  pharmacokinetics  /  UPLC-FLD
Li-rong LIU, Zhi-xin JIA, Xiao-ning YAN, Mei-xia ZHU, Cong FANG, Meng-han FENG, Bei-bei HUANG, Jie LIU, Qian LI, Hong-bin XIAO. Effect of Chuanxiong Rhizoma on the absorption and clearance of four coumarins in Angelicae Dahuricae Radix[J]. Acta Pharmaceutica Sinica, 2021 , 56 (7) : 1804 -1810 . DOI: 10.16438/j.0513-4870.2021-0592
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Article Info
doi: 10.16438/j.0513-4870.2021-0592
  • Receive Date：2021-04-21
  • Online Date：2025-12-18
  • Published：2021-07-12
Article Data
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History
  • Received：2021-04-21
  • Revised：2021-06-22
Funding
Affiliations
    1. School of Chinese Materia Medical, Beijing University of Chinese Medicine, Beijing 100029, China
    2. Research Center for Chinese Medicine Analysis and Transformation, Beijing University of Chinese Medicine, Beijing 100029, China
    3. Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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