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Preparation and stability evaluation of artemether-loaded mixed micelles composed of the sodium glycocholate and soybean lecithin
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Guang-qing XIAO1, 2, 3, Li WU1, Ting XIONG1, 2, Hai-yan LI1, Wei-feng ZHU2, Dong-xun LI2, Ji-wen ZHANG1, 2, *
Acta Pharmaceutica Sinica | 2021, 56(6) : 1704 - 1711
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Acta Pharmaceutica Sinica | 2021, 56(6): 1704-1711
• Original Articles •
Preparation and stability evaluation of artemether-loaded mixed micelles composed of the sodium glycocholate and soybean lecithin
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Guang-qing XIAO1, 2, 3, Li WU1, Ting XIONG1, 2, Hai-yan LI1, Wei-feng ZHU2, Dong-xun LI2, Ji-wen ZHANG1, 2, *
Affiliations
  • 1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  • 2. Key laboratory of Modern Preparation Chinese Materia Medica of Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
  • 3. Guangdong Food and Drug Vocational-Technical School, Guangzhou 510663, China
Published: 2021-06-12 doi: 10.16438/j.0513-4870.2021-0003
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In this study, artemether (ARM)-loaded mixed micelles (MM) composed of the sodium glycocholate (SGC) and soybean lecithin (SL) were prepared by film dispersion method. The effects of hydration medium, SL mass ratio and total concentration of excipients on the solubilization of ARM were investigated and the stability of MM was evaluated. Results showed that the particle size distribution of SGC-SL-MM prepared by phosphate buffer solution (PBS, pH 7.4, 0.05 mol·L-1) was uniform, with an average size of 3.58 ±0.14 nm and the polydispersity index (PDI) value was 0.16 ±0.04. The solubility of ARM increased significantly from 0.64 ±0.04 mg·mL-1 to 13.7 ±0.13 mg·mL-1 along with the concentration of total excipient increasing from 1.0% to 30.0% (w/w). The calculated results of Arrhenius parameter and storage stability showed that the degradation rate constant of ARM in MM was smaller than that in acetonitrile-PBS (pH 7.4) at either 37 ℃ or 60 ℃. The experimental ARM-MM was clear after storing for two months at 25 ℃ and the degradation of ARM was less than 7.0%. In conclusion, the SGC-SL-MM can not only improve the solubility of ARM in aqueous solution, but also improve its chemical stability in aqueous solution at low temperature.

artemether  /  sodium glycocholate  /  soybean lecithin  /  mixed micelle  /  solubility  /  stability
Guang-qing XIAO, Li WU, Ting XIONG, Hai-yan LI, Wei-feng ZHU, Dong-xun LI, Ji-wen ZHANG. Preparation and stability evaluation of artemether-loaded mixed micelles composed of the sodium glycocholate and soybean lecithin[J]. Acta Pharmaceutica Sinica, 2021 , 56 (6) : 1704 -1711 . DOI: 10.16438/j.0513-4870.2021-0003
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Article Info
doi: 10.16438/j.0513-4870.2021-0003
  • Receive Date：2021-01-01
  • Online Date：2025-12-18
  • Published：2021-06-12
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History
  • Received：2021-01-01
  • Revised：2021-03-04
Funding
Affiliations
    1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
    2. Key laboratory of Modern Preparation Chinese Materia Medica of Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
    3. Guangdong Food and Drug Vocational-Technical School, Guangzhou 510663, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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