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Advances in dendritic cell-based vaccine delivery
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Yi-chi SHEN1, Xue-lian FAN1, Fei WANG1, Gang CHEN1, 2, 3, *
Acta Pharmaceutica Sinica | 2021, 56(9) : 2485 - 2494
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Acta Pharmaceutica Sinica | 2021, 56(9): 2485-2494
• Reviews •
Advances in dendritic cell-based vaccine delivery
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Yi-chi SHEN1, Xue-lian FAN1, Fei WANG1, Gang CHEN1, 2, 3, *
Affiliations
  • 1. Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
  • 2. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China
  • 3. Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou 225009, China
Published: 2021-09-12 doi: 10.16438/j.0513-4870.2021-0452
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Dendritic cells (DCs) are the most powerful and professional antigen-presenting cells (APCs) known at present. They play vital roles in the initiation and regulation of immune responses in body. Therefore, DC-based vaccine delivery system has gradually become a hotspot of basic scientific research and clinical treatment. DCs can be loaded with whole-cell antigens, nucleic acids, peptides, proteins (such as neoantigens) and nanoparticles to induce specific cellular immune responses and humoral immune responses after antigen processing, presentation and targeting delivery in vivo for the prevention and treatment of various diseases including cancers and microorganism infections. Vaccine-based on this technique is called dendritic cell (DC) vaccines. Great process in DC vaccines has been achieved in recent years. Therefore, we reviewed the characteristics of DC, types of DC vaccines and their clinical research progress in this paper.

dendritic cell  /  antigen  /  vaccine  /  adaptive immunity  /  nanoparticle
Yi-chi SHEN, Xue-lian FAN, Fei WANG, Gang CHEN. Advances in dendritic cell-based vaccine delivery[J]. Acta Pharmaceutica Sinica, 2021 , 56 (9) : 2485 -2494 . DOI: 10.16438/j.0513-4870.2021-0452
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doi: 10.16438/j.0513-4870.2021-0452
  • Receive Date：2021-03-28
  • Online Date：2025-12-18
  • Published：2021-09-12
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History
  • Received：2021-03-28
  • Revised：2021-04-29
Funding
Affiliations
    1. Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
    2. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China
    3. Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou 225009, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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