收藏切换
Advances in the pathogenesis of depression based on purinergic system and purine metabolism
收藏切换
PDF
Jia-jun CHEN1, 2, 3, Xue-mei QIN1, 2, 3, Guan-hua DU1, 4, Yu-zhi ZHOU1, 2, 3, *
Acta Pharmaceutica Sinica | 2021, 56(9) : 2464 - 2471
Less
收藏切换
Acta Pharmaceutica Sinica | 2021, 56(9): 2464-2471
Reviews
Advances in the pathogenesis of depression based on purinergic system and purine metabolism
Full
Jia-jun CHEN1, 2, 3, Xue-mei QIN1, 2, 3, Guan-hua DU1, 4, Yu-zhi ZHOU1, 2, 3, *
Affiliations
  • 1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
  • 2. The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China
  • 3. The Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province, Taiyuan 030006, China
  • 4. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2021-09-12 doi: 10.16438/j.0513-4870.2021-0379
Outline
收藏切换

Depression was a complex and difficult to regulate disease, which was closely related to purinergic system and purine metabolism disorder. Although there had been studies to improve depression by regulating purinergic system, the mechanism of action was complex and needed to be sorted out. Recently, a large number of studies had found that the addition of exogenous purine metabolites adenosine, inosine and guanosine had a significant antidepressant effect, indicating that regulating the level of purine substances in purine metabolism could also improve depression, which was of great significance to the further study of the pathogenesis and treatment of depression. In view of this, this study reviewed the relationship between purinergic system or purine metabolism and depression, in order to provide a reference for the further study of the pathogenesis of depression.

purinergic  /  purine metabolism  /  depression  /  mechanism  /  adenosine  /  inosine  /  guanosine
Jia-jun CHEN, Xue-mei QIN, Guan-hua DU, Yu-zhi ZHOU. Advances in the pathogenesis of depression based on purinergic system and purine metabolism[J]. Acta Pharmaceutica Sinica, 2021 , 56 (9) : 2464 -2471 . DOI: 10.16438/j.0513-4870.2021-0379
Year 2021 volume 56 Issue 9
PDF
228
99
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2021-0379
  • Receive Date:2021-03-17
  • Online Date:2025-12-18
  • Published:2021-09-12
Article Data
Affiliations
History
  • Received:2021-03-17
  • Revised:2021-04-23
Funding
Affiliations
    1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
    2. The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China
    3. The Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province, Taiyuan 030006, China
    4. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2021-0379
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT