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Preparation, characterization and in vitro release of berberine hydrochloride resin complex
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Tian-yi ZHANG, Ruo-fei DU, You-jie WANG, Jia-liang HU, Fei WU*, Yi FENG*
Acta Pharmaceutica Sinica | 2021, 56(8) : 2282 - 2288
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Acta Pharmaceutica Sinica | 2021, 56(8): 2282-2288
• Original Articles •
Preparation, characterization and in vitro release of berberine hydrochloride resin complex
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Tian-yi ZHANG, Ruo-fei DU, You-jie WANG, Jia-liang HU, Fei WU*, Yi FENG*
Affiliations
  • Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Published: 2021-08-12 doi: 10.16438/j.0513-4870.2021-0347
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The object of this study is to preparate the berberine hydrochloride (BBH) resin compound with taste masking effect. We took the BBH as the model drug and Amberlite IRP69 as the drug carriers, uncovered the curve of solubility of BBH in different cosolvent with a certain range of temperature, and then used it to calculate the parameters during the preparation of the complex such as adding quantity of BBH and the reaction temperature. Afterwards, the characteristic and in vitro release experiments were studied to verify the formation and predict the in vivo release behavior of the complex. The results showed that in the condition of using 60% ethanol as a cosolvent and stirring at 50℃ for 1 h, the drug loading and drug availability of the complex are at about 35% and 64%, respectively, and has a better taste-masking effect. In this study, a method was provided for preparing a taste-masking preparation of BBH.

berberine hydrochloride  /  ion exchange resin  /  taste masking  /  drug-resin complex  /  solubility
Tian-yi ZHANG, Ruo-fei DU, You-jie WANG, Jia-liang HU, Fei WU, Yi FENG. Preparation, characterization and in vitro release of berberine hydrochloride resin complex[J]. Acta Pharmaceutica Sinica, 2021 , 56 (8) : 2282 -2288 . DOI: 10.16438/j.0513-4870.2021-0347
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doi: 10.16438/j.0513-4870.2021-0347
  • Receive Date：2021-03-09
  • Online Date：2025-12-18
  • Published：2021-08-12
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  • Received：2021-03-09
  • Revised：2021-04-12
Affiliations
    Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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