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The effect of acute hypobaric hypoxia on bile acid composition in the small intestine of rats
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Ya-ting ZHANG1, 2, Long-ji HUANG1, 2, An-peng ZHAO2, Yue-mei SUN2, Wen-bin LI2, Juan-hong ZHANG2, 3, *, Rong WANG1, 2, *
Acta Pharmaceutica Sinica | 2021, 56(8) : 2260 - 2265
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Acta Pharmaceutica Sinica | 2021, 56(8): 2260-2265
• Original Articles •
The effect of acute hypobaric hypoxia on bile acid composition in the small intestine of rats
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Ya-ting ZHANG1, 2, Long-ji HUANG1, 2, An-peng ZHAO2, Yue-mei SUN2, Wen-bin LI2, Juan-hong ZHANG2, 3, *, Rong WANG1, 2, *
Affiliations
  • 1. School of Pharmacy, Lanzhou University, Lanzhou 730000, China
  • 2. Department of Pharmacy, the 940th Hospital of Joint Logistics Support Force, PLA, Lanzhou 730050, China
  • 3. College of Life Science, Northwest Normal University, Lanzhou 730030, China
Published: 2021-08-12 doi: 10.16438/j.0513-4870.2021-0200
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In order to clarify the influence of acute hypobaric hypoxia on the bile acids of the rat small intestine, we used ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) to identify bile acids in the contents of the small intestine from untreated and acute hypobaric hypoxia-treated rats. Thirty-nine bile acids were detected; PCA and OPLS-DA analysis revealed marked differences in the composition of bile acids between the untreated and the acute hypobaric hypoxia groups. Bile acids were screened with VIP > 1, |log2FC|≥ 1, P < 0.05, and a total of 7 bile acids with significant differences in content between the two groups were obtained, including 5 conjugated bile acids, 2 unconjugated bile acids; in addition, the content of conjugated bile acids has risen in the treated group. This study demonstrated the influence of high-altitude hypoxic environment on bile acid composition and metabolism in rats. All the animal experiments in this study were approved by the 940th Hospital Ethics Committee (approval No: 2020KYLL012).

bile acid  /  UHPLC-MS/MS  /  acute hypobaric hypoxia  /  metabolomics  /  multivariate statistical analysis
Ya-ting ZHANG, Long-ji HUANG, An-peng ZHAO, Yue-mei SUN, Wen-bin LI, Juan-hong ZHANG, Rong WANG. The effect of acute hypobaric hypoxia on bile acid composition in the small intestine of rats[J]. Acta Pharmaceutica Sinica, 2021 , 56 (8) : 2260 -2265 . DOI: 10.16438/j.0513-4870.2021-0200
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Article Info
doi: 10.16438/j.0513-4870.2021-0200
  • Receive Date：2021-02-01
  • Online Date：2025-12-18
  • Published：2021-08-12
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History
  • Received：2021-02-01
  • Revised：2021-04-21
Funding
Affiliations
    1. School of Pharmacy, Lanzhou University, Lanzhou 730000, China
    2. Department of Pharmacy, the 940th Hospital of Joint Logistics Support Force, PLA, Lanzhou 730050, China
    3. College of Life Science, Northwest Normal University, Lanzhou 730030, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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