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Secondary metabolites of endophyte Alternaria sp. W-1 from Laminaria japonica
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Sha-sha WANG1, 2, Xi CHEN3, Feng-wu WANG4, Ya-ping XU1, 2, Tong YE1, 2, Li SHEN1, 2, *
Acta Pharmaceutica Sinica | 2021, 56(8) : 2248 - 2251
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Acta Pharmaceutica Sinica | 2021, 56(8): 2248-2251
• Original Articles •
Secondary metabolites of endophyte Alternaria sp. W-1 from Laminaria japonica
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Sha-sha WANG1, 2, Xi CHEN3, Feng-wu WANG4, Ya-ping XU1, 2, Tong YE1, 2, Li SHEN1, 2, *
Affiliations
  • 1. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China
  • 2. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225001, China
  • 3. Yangzhou Hospital of TCM, Yangzhou 225001, China
  • 4. College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China
Published: 2021-08-12 doi: 10.16438/j.0513-4870.2021-0488
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Six compounds were isolated from the crude extract of the liquid culture of Alternaria sp. W-1 by silica gel column chromatography, Sephadex LH-20 gel column chromatography, and HPLC. They were identified as 6-iso-tricycloalternarene 6a (1), tricycloalternarene 6a (2), tricycloalternarene B (3), uracil (4), 5-methyluracil (5), and lumichrome (6) through HR-MS, NMR and literature comparison. 6-iso-Tricycloalternarene 6a (1) is a new compound which has never been reported in the literature. In cytotoxicity assay, compounds 1-3 showed weak inhibition activity to human hepatoma cell line SMMC-7721 and human gastric cell line SGC-7901.

Laminaria japonica  /  endophyte  /  Alternaria sp.  /  secondary metabolite  /  tricycloalternarene compound
Sha-sha WANG, Xi CHEN, Feng-wu WANG, Ya-ping XU, Tong YE, Li SHEN. Secondary metabolites of endophyte Alternaria sp. W-1 from Laminaria japonica[J]. Acta Pharmaceutica Sinica, 2021 , 56 (8) : 2248 -2251 . DOI: 10.16438/j.0513-4870.2021-0488
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Article Info
doi: 10.16438/j.0513-4870.2021-0488
  • Receive Date：2021-04-06
  • Online Date：2025-12-18
  • Published：2021-08-12
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History
  • Received：2021-04-06
  • Revised：2021-04-28
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Affiliations
    1. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China
    2. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou 225001, China
    3. Yangzhou Hospital of TCM, Yangzhou 225001, China
    4. College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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