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Four new dammarane-type triterpenoid saponins from Gynostemma longipes C.Y.Wu
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Qi LI1, 2, Xu PANG2, Peng-xin LU1, 2, Jie ZHANG2, Jun ZHANG3, Dong-xiao SHI3, Bai-ping MA1, 2, *
Acta Pharmaceutica Sinica | 2021, 56(6) : 1670 - 1676
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Acta Pharmaceutica Sinica | 2021, 56(6): 1670-1676
• Original Articles •
Four new dammarane-type triterpenoid saponins from Gynostemma longipes C.Y.Wu
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Qi LI1, 2, Xu PANG2, Peng-xin LU1, 2, Jie ZHANG2, Jun ZHANG3, Dong-xiao SHI3, Bai-ping MA1, 2, *
Affiliations
  • 1. Guangdong Pharmaceutical University, Guangzhou 510060, China
  • 2. Institute of Radiation Medicine, Academy of Military Medical Science, Academy of Military Sciences, Beijing 100850, China
  • 3. AnKang Chia Tai Pharmaceutical Co. Ltd., Ankang 725000, China
Published: 2021-06-12 doi: 10.16438/j.0513-4870.2021-0286
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Dammarane-type triterpenoid saponins are regarded as the main active constituents of Gynostemma longipes C.Y.Wu. By using MCI and silica gel column chromatography, as well as preparative HPLC, we isolated four new dammarane-type triterpenoid saponins from the polar saponin fraction of G. longipes C.Y.Wu. Their structures were determined by comprehensive analyses of NMR and MS data and identified as (20S)-3β, 20, 21-trihydroxydammar-19-oxo-24-ene-3-O-{[α-L-rhamnopyranosyl(1→2)]-[β-D-xylopyranosyl(1→3)]-α-L-arabinopyranosyl}-21-O-β-D-glucopyranosyl(1→6)-β-D-glucopyranoside (1), (20S)-3β, 20, 21-trihydroxydammar-24-ene-19-oxo-3-O-[α-L-rhamnopyranosyl(1→2)]-[β-D-xylopyranosyl(1→3)]-α-L-arabinopyranosyl-21-O-α-L-rhamnopyranosyl(1→6)-β-D-glucopyranoside (2), (20S)-3β, 19, 20, 21-terahydroxydammar-24-ene-3-O-{[α-L-rhamnopyranosyl(1→2)]-[β-D-xylopyranosyl(1→3)]-α-L-arabinopyranosyl}-21-O-[β-D-glucopyranosyl(1→6)]-β-D-glucopyranoside (3), (20S)-3β, 20, 21-trihydroxydammar-24-ene-3-O-{[α-L-rhamnopyranosyl(1→2)]-[β-D-glucopyranosyl(1→3)]-β-D-glucopyranosyl}-21-O-[β-D-glucopyranosyl(1→6)]-β-D-glucopyranoside (4). Compounds 1-4 are new dammarane-type triterpenoid saponins which contain five glycosyl residues.

Cucurbitaceae  /  Gynostemma longipes  /  triterpenoid saponins  /  isolation  /  structural elucidation
Qi LI, Xu PANG, Peng-xin LU, Jie ZHANG, Jun ZHANG, Dong-xiao SHI, Bai-ping MA. Four new dammarane-type triterpenoid saponins from Gynostemma longipes C.Y.Wu[J]. Acta Pharmaceutica Sinica, 2021 , 56 (6) : 1670 -1676 . DOI: 10.16438/j.0513-4870.2021-0286
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Article Info
doi: 10.16438/j.0513-4870.2021-0286
  • Receive Date：2021-03-01
  • Online Date：2025-12-18
  • Published：2021-06-12
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History
  • Received：2021-03-01
  • Revised：2021-03-16
Funding
Affiliations
    1. Guangdong Pharmaceutical University, Guangzhou 510060, China
    2. Institute of Radiation Medicine, Academy of Military Medical Science, Academy of Military Sciences, Beijing 100850, China
    3. AnKang Chia Tai Pharmaceutical Co. Ltd., Ankang 725000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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