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Establishment of high-resolution bioassay profiling platform to screen α-glucosidase inhibitors from Malus hupehensis
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Ling-ling XI1, Jing-yi JIAN1, Ding-sheng ZHA2, Xiang-long ZHAO1, 3, Jin-cai WANG1, Juan LI4, Zheng-jin JIANG1, *, Ting-ting ZHANG1, *
Acta Pharmaceutica Sinica | 2021, 56(9) : 2419 - 2425
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Acta Pharmaceutica Sinica | 2021, 56(9): 2419-2425
• Special Reports: Bioanalysis for Drug •
Establishment of high-resolution bioassay profiling platform to screen α-glucosidase inhibitors from Malus hupehensis
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Ling-ling XI1, Jing-yi JIAN1, Ding-sheng ZHA2, Xiang-long ZHAO1, 3, Jin-cai WANG1, Juan LI4, Zheng-jin JIANG1, *, Ting-ting ZHANG1, *
Affiliations
  • 1. Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, Guangzhou 510632, China
  • 2. The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
  • 3. SCIEX(China) Co., Ltd., Guangzhou 510623, China
  • 4. College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China
Published: 2021-09-12 doi: 10.16438/j.0513-4870.2021-0886
Outline
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α-Glucosidase inhibitors play an important role in the treatment of diabetes. This study established a high-resolution bioassay profiling platform for rapidly screening α-glucosidase inhibitors in natural product extracts. Five α-glucosidase inhibitors were identified from Malus hupehensis, namely, 3-hydroxyphloridzin, quercetin-3-O-β-D-glucopyranoside, phloridzin, avicularin and quercitrin. The establishment and successful application of this platform provides a powerful tool for the efficient discovery of anti-diabetic active ingredients in complex systems.

high-resolution bioassay profiling platform  /  Malus hupehensis  /  type 2 diabetes  /  α-glucosidase inhibitor  /  active screening
郗玲玲, 简敬一, 査丁胜, 赵祥龙, 汪锦才, 李娟, 江正瑾, 张婷婷. 基于近线高分辨活性轮廓分析的湖北海棠中α-葡萄糖苷酶抑制剂筛选研究. 药学学报, 2021 , 56 (9) : 2419 -2425 . DOI: 10.16438/j.0513-4870.2021-0886
Ling-ling XI, Jing-yi JIAN, Ding-sheng ZHA, Xiang-long ZHAO, Jin-cai WANG, Juan LI, Zheng-jin JIANG, Ting-ting ZHANG. Establishment of high-resolution bioassay profiling platform to screen α-glucosidase inhibitors from Malus hupehensis[J]. Acta Pharmaceutica Sinica, 2021 , 56 (9) : 2419 -2425 . DOI: 10.16438/j.0513-4870.2021-0886
Appendix
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Year 2021 volume 56 Issue 9
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Article Info
doi: 10.16438/j.0513-4870.2021-0886
  • Receive Date：2021-06-18
  • Online Date：2025-12-18
  • Published：2021-09-12
Article Data
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History
  • Received：2021-06-18
  • Revised：2021-08-05
Funding
Affiliations
    1. Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, Guangzhou 510632, China
    2. The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
    3. SCIEX(China) Co., Ltd., Guangzhou 510623, China
    4. College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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