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Glycyrrhizic acid: a potential drug against COVID-19
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Fu-jing GE1, Chen-ming ZENG1, Fang-jie YAN2, Mei-jia QIAN1, Wei-hua WANG1, Pei-hua LUO1, Qin-jie WENG1, Rang-xiao ZHUANG3, Jian-jun XI3, Jin-song HUANG3, Bo YANG1, Hong ZHU1, *, Qiao-jun HE1, 2, *
Acta Pharmaceutica Sinica | 2021, 56(5) : 1211 - 1216
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Acta Pharmaceutica Sinica | 2021, 56(5): 1211-1216
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Glycyrrhizic acid: a potential drug against COVID-19
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Fu-jing GE1, Chen-ming ZENG1, Fang-jie YAN2, Mei-jia QIAN1, Wei-hua WANG1, Pei-hua LUO1, Qin-jie WENG1, Rang-xiao ZHUANG3, Jian-jun XI3, Jin-song HUANG3, Bo YANG1, Hong ZHU1, *, Qiao-jun HE1, 2, *
Affiliations
  • 1. Zhejiang Province Key Laboratory of Anti-cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
  • 2. Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou 310018, China
  • 3. Xixi Hospital of Hangzhou, Hangzhou 310023, China
Published: 2021-05-12 doi: 10.16438/j.0513-4870.2020-1894
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Pneumonia caused by SARS-CoV-2 has seriously threatened human life and health worldwide and caused a large number of deaths. Viral infection and acute inflammation are important causes of death, so it is particularly important to combine antiviral therapy with anti-inflammatory therapy. Glycyrrhizic acid, the main component of the glycyrrhizic root extract, has a wide range of pharmacological effects as well as high efficiency and low toxicity, its preparation has been widely used in the treatment of chronic hepatitis and other diseases. Glycyrrhizic acid can regulate the expression and release of a variety of cytokines and play a significant anti-inflammatory effect. At the same time, glycyrrhizic acid also showed significant inhibition towards a variety types of viruses. Therefore, the potential application of glycyrrhizic acid as COVID-19 treatment should be explored.

SARS-CoV-2  /  COVID-19  /  glycyrrhizic acid  /  cytokine storm  /  anti-inflammatory treatment  /  antiviral therapy
Fu-jing GE, Chen-ming ZENG, Fang-jie YAN, Mei-jia QIAN, Wei-hua WANG, Pei-hua LUO, Qin-jie WENG, Rang-xiao ZHUANG, Jian-jun XI, Jin-song HUANG, Bo YANG, Hong ZHU, Qiao-jun HE. Glycyrrhizic acid: a potential drug against COVID-19[J]. Acta Pharmaceutica Sinica, 2021 , 56 (5) : 1211 -1216 . DOI: 10.16438/j.0513-4870.2020-1894
Year 2021 volume 56 Issue 5
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doi: 10.16438/j.0513-4870.2020-1894
  • Receive Date:2020-12-08
  • Online Date:2025-12-18
  • Published:2021-05-12
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  • Received:2020-12-08
  • Revised:2021-01-11
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Affiliations
    1. Zhejiang Province Key Laboratory of Anti-cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
    2. Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou 310018, China
    3. Xixi Hospital of Hangzhou, Hangzhou 310023, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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