Home Journals Articles Updates About
CN
image
收藏切换
Tert-butanol application and related research progress in biomedicine
收藏切换
PDF
Hong-liang WANG1, Wu-jun DONG2, Lei CHEN3, Jun YE1, Yan-bao WANG1, Yu-ling LIU1, *
Acta Pharmaceutica Sinica | 2021, 56(9) : 2513 - 2521
Less
收藏切换
Acta Pharmaceutica Sinica | 2021, 56(9): 2513-2521
• Reviews •
Tert-butanol application and related research progress in biomedicine
Full
Hong-liang WANG1, Wu-jun DONG2, Lei CHEN3, Jun YE1, Yan-bao WANG1, Yu-ling LIU1, *
Affiliations
  • 1. Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
  • 2. Center for Drug Evaluation, National Medical Products Administration, Beijing 100038, China
  • 3. Chinese Pharmacopoeia Commission, Beijing 100061, China
Published: 2021-09-12 doi: 10.16438/j.0513-4870.2021-0785
Outline
收藏切换

Tert-butanol is an organic solvent, widely used in the medical field and chemical industry. It could be characterized by high crystallization temperature and vapor pressure. It could be easily sublimed and removed during the freeze-drying process. This review mainly describes the use of tert-butanol in the lyophilized formulations of poorly soluble drugs, the lyophilization solvent of porous structure productions, and as an ice crystal growth guider. In addition, the application of tert-butanol in nano drugs and aerogels has also been reviewed, as well as the current research progress in its quality and safety.

tert-butanol  /  pharmaceutical preparation  /  poorly water-soluble drug  /  freeze drying  /  safety
Hong-liang WANG, Wu-jun DONG, Lei CHEN, Jun YE, Yan-bao WANG, Yu-ling LIU. Tert-butanol application and related research progress in biomedicine[J]. Acta Pharmaceutica Sinica, 2021 , 56 (9) : 2513 -2521 . DOI: 10.16438/j.0513-4870.2021-0785
Appendix
Less
Year 2021 volume 56 Issue 9
PDF
167
74
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2021-0785
  • Receive Date：2021-05-24
  • Online Date：2025-12-18
  • Published：2021-09-12
Article Data
Affiliations
History
  • Received：2021-05-24
  • Revised：2021-06-22
Funding
Affiliations
    1. Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
    2. Center for Drug Evaluation, National Medical Products Administration, Beijing 100038, China
    3. Chinese Pharmacopoeia Commission, Beijing 100061, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2021-0785
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House