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The role of HIF-VEGF-Ang-2 signal transduction-mediated synovial angiogenesis in rheumatoid arthritis
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Pei-rong GAN1, Chao LIU2, Hong WU1, *, Xin-tong DONG1, Jiang-tao KE1, Fang-yuan CHEN1
Acta Pharmaceutica Sinica | 2021, 56(5) : 1246 - 1252
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Acta Pharmaceutica Sinica | 2021, 56(5): 1246-1252
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The role of HIF-VEGF-Ang-2 signal transduction-mediated synovial angiogenesis in rheumatoid arthritis
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Pei-rong GAN1, Chao LIU2, Hong WU1, *, Xin-tong DONG1, Jiang-tao KE1, Fang-yuan CHEN1
Affiliations
  • 1. Anhui Province Key Laboratory of Research and Development of Chinese Medicine, Key Lab of Xin'an Medicine, Ministry of Education, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
  • 2. School of Basic Medicine, Anhui Medical University, Hefei 230032, China
Published: 2021-05-12 doi: 10.16438/j.0513-4870.2021-0238
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Rheumatoid arthritis (RA) is an autoimmune disease with angiogenesis, inflammatory factor infiltration and joint destruction as the main pathological features. Angiogenesis promotes the development of RA and plays an important role in its pathogenesis. The hypoxia-inducible factor (HIF)-vascular endothelial growth factor (VEGF)-angiopoietin-2 (Ang-2) signal transduction is a critical pathway to induce synovial angiogenesis. Targeting HIF-VEGF-Ang-2 signal transduction to inhibit synovial angiogenesis is a promising approach for RA treatment. This article reviews the role and mechanism of HIF-VEGF-Ang-2 signal transduction-mediated synovial angiogenesis in RA, in order to provide a new target and strategy for RA treatment.

rheumatoid arthritis  /  angiogenesis  /  hypoxia-inducible factor  /  vascular endothelial growth factor  /  angiopoietin-2
Pei-rong GAN, Chao LIU, Hong WU, Xin-tong DONG, Jiang-tao KE, Fang-yuan CHEN. The role of HIF-VEGF-Ang-2 signal transduction-mediated synovial angiogenesis in rheumatoid arthritis[J]. Acta Pharmaceutica Sinica, 2021 , 56 (5) : 1246 -1252 . DOI: 10.16438/j.0513-4870.2021-0238
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Article Info
doi: 10.16438/j.0513-4870.2021-0238
  • Receive Date：2021-02-19
  • Online Date：2025-12-18
  • Published：2021-05-12
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History
  • Received：2021-02-19
  • Revised：2021-03-22
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Affiliations
    1. Anhui Province Key Laboratory of Research and Development of Chinese Medicine, Key Lab of Xin'an Medicine, Ministry of Education, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China
    2. School of Basic Medicine, Anhui Medical University, Hefei 230032, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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