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Research progress in the application of glass transition phenomenon in pharmaceutics
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Qiu-fang CAO1, Xiao-yong RAO1, Yao ZHANG1, Ai-ling ZHANG1, Min LI2, Zhe LI1, *, Xiao-jian LUO1, *
Acta Pharmaceutica Sinica | 2021, 56(5) : 1301 - 1313
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Acta Pharmaceutica Sinica | 2021, 56(5): 1301-1313
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Research progress in the application of glass transition phenomenon in pharmaceutics
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Qiu-fang CAO1, Xiao-yong RAO1, Yao ZHANG1, Ai-ling ZHANG1, Min LI2, Zhe LI1, *, Xiao-jian LUO1, *
Affiliations
  • 1. National Pharmaceutical Engineering Research Center for Solid Preparation in Chinese Herbal Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
  • 2. Yangzijiang Pharmaceutical Group Co., LTD., Taizhou 225300, China
Published: 2021-05-12 doi: 10.16438/j.0513-4870.2020-1755
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In recent years, the phenomenon of glass transition has been gradually applied to the field of pharmaceutics. And it exhibits important influences on multiple operating units of pharmaceutical preparations, and the properties and storage of pharmaceutical intermediates and products. At present, it has been widely used in the process of preparations such as drying, granulation, coating, tableting, holt-melt extrusion, cryogenic comminution, and so on. Meanwhile, it showed guiding significance for the process of preparation intermediates and their products, such as solid dispersion, microcapsule, liposome, particle, tablet, and other preparation intermediates and their products. Therefore, this article conducts a detailed analysis and systematic summary of the application guidance of the phenomenon of glass transition in the preparation process, and its influence on the preparation intermediates and products, so as to provide theoretical guidance for preparation production and product storage.

glass transition  /  amorphous  /  temperature  /  moisture content  /  pharmaceutics  /  stability
Qiu-fang CAO, Xiao-yong RAO, Yao ZHANG, Ai-ling ZHANG, Min LI, Zhe LI, Xiao-jian LUO. Research progress in the application of glass transition phenomenon in pharmaceutics[J]. Acta Pharmaceutica Sinica, 2021 , 56 (5) : 1301 -1313 . DOI: 10.16438/j.0513-4870.2020-1755
Year 2021 volume 56 Issue 5
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Article Info
doi: 10.16438/j.0513-4870.2020-1755
  • Receive Date:2020-11-17
  • Online Date:2025-12-18
  • Published:2021-05-12
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History
  • Received:2020-11-17
  • Revised:2021-01-15
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Affiliations
    1. National Pharmaceutical Engineering Research Center for Solid Preparation in Chinese Herbal Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
    2. Yangzijiang Pharmaceutical Group Co., LTD., Taizhou 225300, China
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表12种不同金属材料的力学参数

Family
属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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