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A novel dimeric diterpenoid alkaloid from the Tibetan medicinal plant Aconitum tanguticum (Maxim.) Stapf
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Li-hua YANG1, 2, Yue WANG1, 3, Xiao-qian LIU1, Yao-hua LIANG1, Chun LI1, *, Zhi-min WANG1, *
Acta Pharmaceutica Sinica | 2021, 56(5) : 1429 - 1433
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Acta Pharmaceutica Sinica | 2021, 56(5): 1429-1433
• Original Articles •
A novel dimeric diterpenoid alkaloid from the Tibetan medicinal plant Aconitum tanguticum (Maxim.) Stapf
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Li-hua YANG1, 2, Yue WANG1, 3, Xiao-qian LIU1, Yao-hua LIANG1, Chun LI1, *, Zhi-min WANG1, *
Affiliations
  • 1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • 2. Hunan University of Science and Engineering, Yongzhou 425199, China
  • 3. Guangdong Pharmaceutical University, Guangzhou 510006, China
Published: 2021-05-12 doi: 10.16438/j.0513-4870.2020-1912
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Two dimeric diterpenoid alkaloids were isolated from the whole plant of Aconitum tanguticum (Maxim.) Stapf and their structures were elucidated by extensive analysis of 1D, 2D-NMR and HR-MS data. One is a new compound and named tanguticurine A (1), and the other is the known compound anthoroidine B (2); both were isolated from this plant for the first time. The antiviral activity of compounds 1 and 2 against HCV and EV71 were also evaluated. It was found that compound 1 had a good inhibitory effect on HCV and EV71 with EC50 values of 15.5 and 9.7 μmol·L-1, respectively, and showed low cytotoxicity. Therefore, compound 1 is a good antiviral lead compound and deserves further study.

Aconitum tanguticum  /  diterpenoid alkaloid  /  structural elucidation  /  antiviral activity
Li-hua YANG, Yue WANG, Xiao-qian LIU, Yao-hua LIANG, Chun LI, Zhi-min WANG. A novel dimeric diterpenoid alkaloid from the Tibetan medicinal plant Aconitum tanguticum (Maxim.) Stapf[J]. Acta Pharmaceutica Sinica, 2021 , 56 (5) : 1429 -1433 . DOI: 10.16438/j.0513-4870.2020-1912
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Year 2021 volume 56 Issue 5
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Article Info
doi: 10.16438/j.0513-4870.2020-1912
  • Receive Date：2020-12-16
  • Online Date：2025-12-18
  • Published：2021-05-12
Article Data
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History
  • Received：2020-12-16
  • Revised：2021-01-07
Funding
Affiliations
    1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
    2. Hunan University of Science and Engineering, Yongzhou 425199, China
    3. Guangdong Pharmaceutical University, Guangzhou 510006, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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