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Effect of compound houttuynia mixture on influenza virus in vitro
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Hai-yan YAN1, Meng WANG1, Hui-qiang WANG1, Ping-hu ZHANG2, Han-tai JIN3, Yu-huan LI1, *
Acta Pharmaceutica Sinica | 2021, 56(5) : 1409 - 1415
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Acta Pharmaceutica Sinica | 2021, 56(5): 1409-1415
• Original Articles •
Effect of compound houttuynia mixture on influenza virus in vitro
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Hai-yan YAN1, Meng WANG1, Hui-qiang WANG1, Ping-hu ZHANG2, Han-tai JIN3, Yu-huan LI1, *
Affiliations
  • 1. CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, China
  • 3. Zhejiang Conbazy Chinese Medicine Co., Ltd., Lishui 323400, China
Published: 2021-05-12 doi: 10.16438/j.0513-4870.2020-1881
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Compound houttuynia mixture belongs to OTC class A medicine, which is made from Houttuynia cordata, Scutellaria baicalensis, Radix Isatidis, Forsythia, and Lonicera. As a kind of compound preparation of traditional Chinese medicine, houttuynia cordata mixture has extensive pharmacological effects, for example, clearing away heat and detoxifying, thus it is used for the sore throat, acute pharyngitis, and tonsillitis with wind-heat syndrome. In this study, the antiviral activity against influenza viruses and the primary mechanism of compound houttuynia mixture was evaluated. The antiviral effect of compound houttuynia mixture was determined by cytopathic effects (CPE), Western blot, quantitive reverse transcription PCR (qRT-PCR), and virus titer assays. The effect of houttuynia mixture on the replication cycle of influenza virus was evaluated by time-of-addition assay. In conclusion, the results showed that the compound houttuynia mixture had a broad-spectrum effect against influenza virus, including the international common influenza virus strains, the drug-resistant strains and the highly pathogenic avian influenza viruses H5N1 and H7N9. It mainly impairs the early stage of the viral replication.

compound houttuynia mixture  /  a broad-spectrum antiviral effect  /  highly pathogenic avian influenza virus  /  resistant strain  /  anti-influenza virus agent
Hai-yan YAN, Meng WANG, Hui-qiang WANG, Ping-hu ZHANG, Han-tai JIN, Yu-huan LI. Effect of compound houttuynia mixture on influenza virus in vitro[J]. Acta Pharmaceutica Sinica, 2021 , 56 (5) : 1409 -1415 . DOI: 10.16438/j.0513-4870.2020-1881
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Year 2021 volume 56 Issue 5
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Article Info
doi: 10.16438/j.0513-4870.2020-1881
  • Receive Date：2020-12-08
  • Online Date：2025-12-18
  • Published：2021-05-12
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History
  • Received：2020-12-08
  • Revised：2021-01-26
Funding
Affiliations
    1. CAMS Key Laboratory of Antiviral Drug Research, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, China
    3. Zhejiang Conbazy Chinese Medicine Co., Ltd., Lishui 323400, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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